VISDB Viral Integration Site DataBase

VIS ID

TVIS10018764

Fusion event

HBV-MEG3 integration

Validated

No

Detection method

VirusFinder

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2017

PubMed ID

Virus name

HBV

Reference genome

Start

62

End

968

Integrated sequence

TGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAACATGGAGAACATCACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCGCAGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCA

Chromosome

chr14

Cytoband

q32.2

Reference genome

Start

End

101297871/100831534 (Hg38)

Location type

Exon4

Target gene

miRNAs that regulate target gene

hsa-mir-181a-5p ; hsa-mir-181b-5p ; hsa-mir-181d-5p ; hsa-mir-140-5p ; hsa-mir-133a-3p ; hsa-mir-770-5p ; hsa-mir-125a-5p ; hsa-mir-664a-3p

Nearest miRNA

hsa-mir-1260a/Upstream/16843; hsa-mir-1185-1/Downstream/20856;

Nearest TSS

Nearest CpG islands

None/Target, chr14-CpG: 35/Upstream/3130, chr14-CpG: 23/Downstream/50514

Nearest cancer related gene

MEG3(TSG, No orient, 0)

Upstream sequence

CGAATACTTTTCTAAACATCAAGATACAGCTCAGAACACTTCAATAACAAGATTTGGTCTACTTAGGCATCCGGCTTGACAGCTAAACACTTTAGACCAC

Downstream sequence

gtaaagacttttctgtggcttaatccttgtcatgttttcggctcatGGACACAAGGACACATTTTCATGCCTTCTCTCACAGGGCTCTGCGTCTCCGGTT

Target sequence

cagccaagcttcttgaaaggcctgtctacacttgctgtcttccttcctcacctccaatttcctcttcaacccactgcttcctgactcgctctactccgtggaagcacgctcacaaag