KCNH5 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10018788
Fusion event
HBV-KCNH5 integration
Validated
No
Detection method
VirusFinder
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29212479
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
1809
Integrated sequence
TCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACC| |AGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACA
Host Sequence
Chromosome
chr14
Cytoband
q23.2
Reference genome
GRCh37.55
Start
63364363/62897645 (Hg38)
End
63364363/62897645 (Hg38)
Location type
Intron3
Fragile sites / regions
FRA14B
Target gene
KCNH5
miRNAs that regulate target gene
hsa-mir-514b-5p ; hsa-mir-513c-5p ; hsa-mir-5704 ; hsa-mir-3926 ; hsa-mir-548o-3p ; hsa-mir-1295b-3p ; hsa-mir-1323 ; hsa-mir-15a-3p ; hsa-mir-4717-5p ; hsa-mir-5582-3p
Nearest miRNA
hsa-mir-208a/Upstream/2248934; hsa-mir-1185-1/Downstream/1197379;
Nearest TSS
ENST00000550708/Upstream/757672; ENST00000557133/Downstream/147541;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/780084, chr14-CpG: 96/Downstream/147644
Upstream sequence
TCTTCATATGCTTGACTTCCTCCTGTATTGGTGAGAATGGAGTGTTTGTCTTCTTGTCCTTCAGCAACATAAAATACTGCAATCTTGTGTGTCTCTCGGC
Downstream sequence
ACAGCACAGGAATATTATGAGAACTGATAGATGTCAATAAGTGAAAAAGGAAGAACACAGTTAGGTTAAAAAAAATCAAATGAAAAATGAAACTATTTTA
Reference
Yoo, S., et al. A pilot systematic genomic comparison of recurrence risks of hepatitis B virus-associated hepatocellular carcinoma with low- and high-degree liver fibrosis. BMC Med ,2017, 15(1): 214.
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