EIF4G3 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10018868
Fusion event
HBV-EIF4G3 integration
Validated
No
Detection method
VirusFinder
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29212479
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
1818
Integrated sequence
GTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATG| |CAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTT
Host Sequence
Chromosome
chr1
Cytoband
p36.12
Reference genome
GRCh37.55
Start
21267157/20940664 (Hg38)
End
21267157/20940664 (Hg38)
Location type
Intron23
Fragile sites / regions
FRA1A
Target gene
EIF4G3
miRNAs that regulate target gene
hsa-mir-375 ; hsa-mir-24-3p ; hsa-mir-16-5p ; hsa-mir-221-3p ; hsa-mir-17-5p ; hsa-mir-3613-3p ; hsa-mir-543 ; hsa-mir-136-5p ; hsa-mir-377-5p ; hsa-mir-218-5p ; hsa-mir-548c-3p ; hsa-mir-4724-3p ; hsa-mir-6813-3p ; hsa-mir-3200-3p
Nearest miRNA
hsa-mir-12136/Upstream/306876; hsa-mir-101-1/Downstream/47650;
Nearest TSS
ENST00000473358/Upstream/92719; ENST00000416959/Downstream/734;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/153036, chr1-CpG: 77/Downstream/235958
Upstream sequence
gagaaaacagggacagaagtttgacacagtaaaacagcccaatgctttaatgaggatgtgcaaatatgagtaagtttcatatggaattcttccagactcg
Downstream sequence
TGTGTATAATAGAGAGCGGGTCACAGAAGACAGGTTTCCATGGCTGAGGAAATTGTTCATTATAGCAATCATTTattcattcattcaacaagcatttact
Reference
Yoo, S., et al. A pilot systematic genomic comparison of recurrence risks of hepatitis B virus-associated hepatocellular carcinoma with low- and high-degree liver fibrosis. BMC Med ,2017, 15(1): 214.
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