Basic Information
VIS ID
TVIS10018869
Fusion event
HBV-chr1 integration
Validated
No
Detection method
VirusFinder
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29212479
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
1786
Integrated sequence
AACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGT| |AGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCT
Host Sequence
Chromosome
chr1
Cytoband
p31.3
Reference genome
GRCh37.55
Start
61718748/61253076 (Hg38)
End
61718748/61253076 (Hg38)
Location type
Intron
Fragile sites / regions
FRA1B
Target gene
NFIA ; NFIA-AS1
miRNAs that regulate target gene
hsa-mir-424-5p ; hsa-mir-223-3p ; hsa-mir-107 ; hsa-mir-124-3p ; hsa-mir-193b-3p ; hsa-mir-100-5p ; hsa-mir-190a-3p ; hsa-mir-3924 ; hsa-mir-4496 ; hsa-mir-5011-5p ; hsa-mir-29a-3p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-519d-5p ; hsa-mir-3145-5p ; hsa-mir-21-5p ; hsa-mir-181b-5p ; hsa-mir-382-5p ; hsa-mir-3662 ; hsa-mir-103a-3p ; hsa-mir-4446-5p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-6883-3p ; hsa-mir-335-3p ; hsa-mir-4662a-3p ; hsa-mir-4311 ; hsa-mir-302b-3p
Nearest miRNA
hsa-mir-12136/Upstream/1519780; hsa-mir-101-1/Downstream/592999;
Nearest TSS
ENST00000473358/Upstream/164664; ENST00000482020/Downstream/99374;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/169326, chr1-CpG: 25/Downstream/401126
Upstream sequence
ATGAGAATTAATTAAGTACACTATTTTCCACAGTACACTCCCACGAAGTTTTTAGTGCTGCCATAATGTTTGTAGTAAAAAGAATCAACATTTTCAATTT
Downstream sequence
AAAACTGAAATAAAATAGAGATGGAGGAAAAGTAGCAATTGCCGAAAGTTTGGATATATAAATATGCAAATGTAACATATCCCAGGCTTTAACTCAGTTG
Reference
Yoo, S., et al. A pilot systematic genomic comparison of recurrence risks of hepatitis B virus-associated hepatocellular carcinoma with low- and high-degree liver fibrosis. BMC Med ,2017, 15(1): 214.
Curate