Basic Information
VIS ID
TVIS10018892
Fusion event
HBV-chr4 integration
Validated
No
Detection method
VirusFinder
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29212479
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
1819
Integrated sequence
TTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGC| |AACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTA
Host Sequence
Chromosome
chr4
Cytoband
q22.1
Reference genome
GRCh37.55
Start
90370302/89449151 (Hg38)
End
90370302/89449151 (Hg38)
Fragile sites / regions
FRA4E
Nearest miRNA
hsa-mir-12113/Upstream/2148568; hsa-mir-1243/Downstream/9548236;
Nearest TSS
ENST00000502981/Upstream/141141; ENST00000509723/Downstream/102205;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/141312, chr4-CpG: 70/Downstream/387706
Nearby gene
GPRIN3
Upstream sequence
tAAATTTTTCATTATCTATAGGTAAAAGCACACTTGGAATTAGCAATAGATGCAATTTGGGACTTAACTCTTTCAGTATGTCTTATTTCTAAGCAAAGTA
Downstream sequence
aTGCTAACATTTACTGAGTATGGTGCAACTTTcttttacataaattatctcatttaatcttccgagtaactctCAACCATTTAAATCTGCAGAACACATT
Reference
Yoo, S., et al. A pilot systematic genomic comparison of recurrence risks of hepatitis B virus-associated hepatocellular carcinoma with low- and high-degree liver fibrosis. BMC Med ,2017, 15(1): 214.
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