Basic Information
VIS ID
TVIS10018907
Fusion event
HBV-chr9 integration
Validated
No
Detection method
VirusFinder
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29212479
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
1814
Integrated sequence
GACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCAC| |CATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGAC
Host Sequence
Chromosome
chr9
Cytoband
p21.3
Reference genome
GRCh37.55
Start
25366796/25366798 (Hg38)
End
25366796/25366798 (Hg38)
Fragile sites / regions
FRA9C
Nearest miRNA
hsa-mir-101-2/Upstream/3854613; hsa-let-7a-1/Downstream/3496828;
Nearest TSS
ENST00000422679/Upstream/820800; ENST00000627303/Downstream/311642;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/1515274, chr9-CpG: 111/Downstream/310698
Nearby gene
TUSC1
Nearest cancer related gene
TUSC1(TSG, No orient)
Upstream sequence
CTAAATGGGAGGAAAGGTTACAGAGGCAGAGGGAGCTGAGGACATCAAGGTATTTTCAAGCAAAGGAGAGAATGCATGTGTCTCTTTCCACTCCACTTAC
Downstream sequence
TTCAGATTAAAAGTTCTAAAAACTGATGCATGACACTTTTAGCCAAATCAGAGTATGTTAGCAGAATGTCAAACCCAAACCCAAATACAGTACAAAATAA
Reference
Yoo, S., et al. A pilot systematic genomic comparison of recurrence risks of hepatitis B virus-associated hepatocellular carcinoma with low- and high-degree liver fibrosis. BMC Med ,2017, 15(1): 214.
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