VISDB - VIS Detail

Expression analysis of TCGA samples

Basic Information

VIS ID

TVIS10018936

Fusion event

HBV-PIAS2 integration

Validated

No

Detection method

VirusFinder

Data source

Curated

Sample type

Nontumor

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2017

PubMed ID

29212479

Virus Sequence

Virus name

HBV

Reference genome

NC_003977

Start

1815

Integrated sequence

ACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACC| |ATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACC

Host Sequence

Chromosome

chr18

Cytoband

q21.1

Reference genome

GRCh37.55

Start

44462344/46882381 (Hg38)

End

44462344/46882381 (Hg38)

Location type

Intron12

Target gene

PIAS2

miRNAs that regulate target gene

hsa-mir-26b-5p ; hsa-mir-3658 ; hsa-mir-3653-3p ; hsa-mir-4720-3p ; hsa-mir-6507-5p ; hsa-mir-6126 ; hsa-mir-3140-3p ; hsa-mir-4493 ; hsa-mir-605-3p ; hsa-mir-497-3p ; hsa-mir-498 ; hsa-mir-4279 ; hsa-mir-4713-5p ; hsa-mir-23b-5p ; hsa-mir-23a-5p ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-2116-3p ; hsa-mir-532-3p ; hsa-mir-150-5p ; hsa-mir-6742-3p ; hsa-mir-6747-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-1281 ; hsa-mir-1343-3p ; hsa-mir-4485-5p ; hsa-mir-660-3p ; hsa-mir-6783-3p ; hsa-mir-6791-3p ; hsa-mir-6829-3p ; hsa-mir-6852-5p ; hsa-mir-939-3p ; hsa-mir-129-5p ; hsa-mir-1303 ; hsa-mir-1304-3p ; hsa-mir-133a-3p ; hsa-mir-133b ; hsa-mir-215-3p ; hsa-mir-3664-5p ; hsa-mir-4639-3p ; hsa-mir-5007-5p ; hsa-mir-6758-5p ; hsa-mir-6773-3p ; hsa-mir-6794-3p ; hsa-mir-6843-3p ; hsa-mir-6848-3p ; hsa-mir-6856-5p ; hsa-mir-6879-3p

Nearest miRNA

hsa-mir-1-2/Upstream/1912215; hsa-mir-122/Downstream/498115;

Nearest TSS

ENST00000575820/Upstream/18149; ENST00000585383/Downstream/23849;

Nearest CpG islands

None/Target, chr18-CpG: 67/Upstream/124244, chr18-CpG: 126/Downstream/34566

Upstream sequence

aaggaaaagtcaagctgagaaccgtgtcaggcaagcctgccgcccattttattcctaaataagatagatacaaagataaagctacatgcctctctcacaa

Downstream sequence

tgtatagggaaaacagtacctccacacacacaaatggactacaaattggtgcaatgctgtggaagctactgtcgaatttccctctaaaggtgaatatcaa

Reference

Yoo, S., et al. A pilot systematic genomic comparison of recurrence risks of hepatitis B virus-associated hepatocellular carcinoma with low- and high-degree liver fibrosis. BMC Med ,2017, 15(1): 214.