FHIT _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10018961
Fusion event
HBV-FHIT integration
Validated
No
Detection method
VirusFinder
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2017
PubMed ID
29212479
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Host Sequence
Chromosome
chr3
Cytoband
p14.2
Reference genome
GRCh37.55
Start
60477905/60492172 (Hg38)
End
60477994/60492261 (Hg38)
Location type
Intron5
Fragile sites / regions
FRA3B
Target gene
FHIT
miRNAs that regulate target gene
hsa-mir-143-3p ; hsa-mir-217 ; hsa-mir-331-3p ; hsa-mir-625-5p
Nearest miRNA
hsa-let-7g/Upstream/4639578; hsa-mir-12124/Downstream/125544;
Nearest TSS
ENST00000440867/Upstream/411332; ENST00000475527/Downstream/759123;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/1441954, chr3-CpG: 48/Downstream/758671
Nearest cancer related gene
FHIT(TSG, No orient, 0)
Upstream sequence
cacttgcacttgggaggcggaggtttcagtgagccaagattgcgccactgaactgcagtctgggtgacacagggagactgtgtctcagaaacaaacaaaa
Downstream sequence
TACAAACATTCAGCATTTAAAATATTGATGTCTTTCTGTGGTCACAAAGTCAAATAATTGTTTCTCACATTTGAGCATTAGAATTTGGTATTTAAAATTA
Target sequence
ATTCTTTACTAAAACTAAATTTTACTATATGATGCTTATGTGGAAGGAACAGGCAACATAACTGCAAGACAACAGTAGCTATCTGAAAA
Reference
Yoo, S., et al. A pilot systematic genomic comparison of recurrence risks of hepatitis B virus-associated hepatocellular carcinoma with low- and high-degree liver fibrosis. BMC Med ,2017, 15(1): 214.
Curate