Basic Information
VIS ID
TVIS10018977
Fusion event
HBV-chr7 integration
Validated
No
Detection method
VirusFinder
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2017
PubMed ID
29212479
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Host Sequence
Chromosome
chr7
Cytoband
q11.23
Reference genome
GRCh37.55
Start
74117535/74703206 (Hg38)
End
74117624/74703295 (Hg38)
Location type
Intron
Fragile sites / regions
FRA7J
Target gene
GTF2I ; LOC101926943
miRNAs that regulate target gene
hsa-let-7b-5p ; hsa-mir-21-5p ; hsa-mir-1229-3p ; hsa-mir-10a-3p ; hsa-mir-484 ; hsa-mir-23b-3p ; hsa-mir-99a-5p ; hsa-let-7e-5p ; hsa-let-7a-5p ; hsa-mir-335-3p ; hsa-mir-1305 ; hsa-mir-607 ; hsa-mir-3671 ; hsa-mir-580-5p ; hsa-mir-1252-3p ; hsa-mir-3646 ; hsa-mir-3121-3p
Nearest miRNA
hsa-mir-10525/Upstream/107180; hsa-mir-10399/Downstream/1211902;
Nearest TSS
ENST00000635602/Upstream/18549; ENST00000490431/Downstream/1882;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/44454, chr7-CpG: 124/Downstream/84694
Upstream sequence
AGAAAACTAAGATGAATAAGTTGAGAGACAAAGTCATGAATTTTAATTTACTATGTCATTACAATTATTTTGGAATATATTTTCTTCAAGTCACAGAATC
Downstream sequence
acttgtcttcttcccttacttggtagtatcctttgaggcacaaacgttttaaattttgataaaaataagtttattcttttgttaacttgtgctttttttt
Target sequence
aatggtgtcactctgttatccaggctggagtacaggatttgggaatattttctccaattctaataaatctacattatccttattgtata
Reference
Yoo, S., et al. A pilot systematic genomic comparison of recurrence risks of hepatitis B virus-associated hepatocellular carcinoma with low- and high-degree liver fibrosis. BMC Med ,2017, 15(1): 214.
Curate