Basic Information
VIS ID
TVIS10018998
Fusion event
HBV-chr14 integration
Validated
No
Detection method
VirusFinder
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29212479
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Host Sequence
Chromosome
chr14
Cytoband
q24.1
Reference genome
GRCh37.55
Start
69073405/68606688 (Hg38)
End
69073405/68606688 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA14C
Target gene
LOC107984016 ; RAD51B
miRNAs that regulate target gene
hsa-mir-484 ; hsa-mir-4668-5p ; hsa-mir-2053 ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-30b-3p ; hsa-mir-3689a-3p ; hsa-mir-1273h-5p ; hsa-mir-569 ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-766-5p ; hsa-mir-6871-5p ; hsa-mir-4496 ; hsa-mir-4506
Nearest miRNA
hsa-mir-208a/Upstream/1164758; hsa-mir-1185-1/Downstream/3910132;
Nearest TSS
ENST00000550708/Upstream/61126; ENST00000553944/Downstream/21757;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/931523, chr14-CpG: 40/Downstream/21610
Nearby gene
ZFP36L1
Upstream sequence
ctttatgtaatacccctctttattcttgataattctccttgctctaaagtctgctttgtcatgcactgcataatgatgtttcggtcaccaacagaccgca
Downstream sequence
GAAGGAATCGcatcttagacgaaaacctaggcacagagaagttaagcagctcattcaagatgacacagtttgttattaactgagtcggaactgtacctca
Reference
Yoo, S., et al. A pilot systematic genomic comparison of recurrence risks of hepatitis B virus-associated hepatocellular carcinoma with low- and high-degree liver fibrosis. BMC Med ,2017, 15(1): 214.
Curate