CYP3A5 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10019024
Fusion event
HBV-CYP3A5 integration
Validated
No
Detection method
VirusFinder
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2017
PubMed ID
29212479
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Host Sequence
Chromosome
chr7
Cytoband
q22.1
Reference genome
GRCh37.55
Start
99273737/99676114 (Hg38)
End
99273936/99676313 (Hg38)
Location type
Exon12
Fragile sites / regions
FRA7F
Target gene
CYP3A5
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-599 ; hsa-mir-3161 ; hsa-mir-122-5p ; hsa-mir-504-3p ; hsa-mir-4254 ; hsa-mir-3690 ; hsa-mir-6809-3p ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-3191-5p ; hsa-mir-7162-5p ; hsa-mir-516b-3p ; hsa-mir-516a-3p ; hsa-mir-2115-5p ; hsa-mir-6728-3p ; hsa-mir-4438
Nearest miRNA
hsa-mir-10525/Upstream/266850; hsa-mir-10399/Downstream/417247;
Nearest TSS
ENST00000635602/Upstream/12532; ENST00000608397/Downstream/263;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/58852, chr7-CpG: 76/Downstream/242666
Upstream sequence
gtgttcatcagatgcattaacctgtagttttctttctgtgtgtgtgtgtctttgttagtcttggtatcagggtgatactggactcatagaatgaagtcag
Downstream sequence
TACACGATAAATAATAACAGCAACTCCAACATCAGTAATTGCATTCACTCATCAGGTCCTTTCCTGACTATTCTGAGACCCCTGAAAAGTCTCAATGATT
Target sequence
CTGACGATAGGACAAAACATTTCCCAACAAAGGCAGAGGTGTGGGCCCTGGAATTCCCAGTCTCTTAAAAAGTCCATGTGTACGGGTCCCATATCTACAAAGTGAAACAGAAATCAGGTCACAGGGATTGTGACTTTATAGATCAGAGGGCTGGTGAGTTACTCAGGAACTGGAATGGTCAAGAGAGGGAGGTAATATG
Reference
Yoo, S., et al. A pilot systematic genomic comparison of recurrence risks of hepatitis B virus-associated hepatocellular carcinoma with low- and high-degree liver fibrosis. BMC Med ,2017, 15(1): 214.
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