Basic Information
VIS ID
TVIS10019231
Fusion event
HBV-FYB1 integration
Validated
No
Detection method
VirusFinder
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Host Sequence
Chromosome
chr5
Cytoband
p13.1
Reference genome
GRCh37/hg19
Start
39169330/39169228 (Hg38)
End
39169419/39169317 (Hg38)
Location type
Intron17
Fragile sites / regions
FRA5A
Target gene
FYB1
miRNAs that regulate target gene
hsa-mir-4795-3p ; hsa-mir-613 ; hsa-mir-206 ; hsa-mir-1-3p ; hsa-mir-126-5p ; hsa-mir-4307 ; hsa-mir-656-3p ; hsa-mir-33a-3p ; hsa-mir-513c-3p ; hsa-mir-513a-3p ; hsa-mir-3606-3p
Nearest miRNA
hsa-mir-10397/Upstream/611667; hsa-mir-103a-1/Downstream/14782187;
Nearest TSS
ENST00000502646/Upstream/29198; ENST00000603514/Downstream/33710;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/94094, chr5-CpG: 39/Downstream/255473
Upstream sequence
ATTTCCATAATTAAACACACACACTAACAAGCTTGCttttttttttttttttttttttttgagacggagtctcgccctgtcgcccaggctggagtgcagt
Downstream sequence
TGGGGTATCTTTGGAGAAAAATTCCCAGACGAATACTAAACCGGTCAATTGAACTAGCTTTGTGAATTTTTCCGTACATTCCTGCCAGATTAGTTTCTGT
Target sequence
GTGGTGCATTTCTGGTGTATAAGTCAACAGAACAATCATGACCCAGAGGTGAAGCCAAGCCATATATATAATCACAAAAACTCATGCTA
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
Curate