VISDB Viral Integration Site DataBase

VIS ID

TVIS10019284

Fusion event

HBV-THRB integration

Validated

No

Detection method

VirusFinder

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2012

PubMed ID

Virus name

HBV

Reference genome

Chromosome

chr3

Cytoband

p24.2

Reference genome

Start

End

24494166/24452675 (Hg38)

Location type

Intron10

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-27a-3p ; hsa-mir-204-5p ; hsa-mir-155-5p ; hsa-mir-425-5p ; hsa-mir-452-5p ; hsa-mir-4677-3p ; hsa-mir-4679 ; hsa-mir-3161 ; hsa-mir-3689f ; hsa-mir-3689e ; hsa-mir-3689b-5p ; hsa-mir-3689a-5p ; hsa-mir-3926 ; hsa-mir-4778-5p ; hsa-mir-4753-5p ; hsa-mir-6794-3p ; hsa-mir-3152-5p ; hsa-mir-6836-3p ; hsa-mir-15b-3p ; hsa-mir-4264 ; hsa-mir-4797-3p ; hsa-mir-6809-3p ; hsa-mir-4753-3p ; hsa-mir-4436b-5p ; hsa-mir-6509-3p ; hsa-mir-1236-3p ; hsa-mir-6515-3p ; hsa-mir-101-3p ; hsa-mir-200a-3p ; hsa-mir-1238-5p ; hsa-mir-129-5p ; hsa-mir-3659 ; hsa-mir-4658 ; hsa-mir-4758-5p ; hsa-mir-574-5p ; hsa-mir-6790-5p ; hsa-mir-8055 ; hsa-mir-8081 ; hsa-mir-1537-5p ; hsa-mir-320a ; hsa-mir-320b ; hsa-mir-320c ; hsa-mir-320d ; hsa-mir-3607-3p ; hsa-mir-4429 ; hsa-mir-4633-3p ; hsa-mir-4793-5p ; hsa-mir-5002-5p ; hsa-mir-5196-3p ; hsa-mir-6500-5p ; hsa-mir-6870-3p ; hsa-mir-6874-5p ; hsa-mir-9-3p

Nearest miRNA

hsa-mir-12127/Upstream/4314945; hsa-let-7g/Downstream/1212198;

Nearest TSS

Nearest CpG islands

None/Target, chr3-CpG: 148/Upstream/506056, chr3-CpG: 135/Downstream/41678

Nearest cancer related gene

THRB(TSG, No orient, 0)

Upstream sequence

ATTGTTTTCATTATTATTTTTAACTTACAACAACTGGAGTTTGGCTTGTCAAGAGTCGTGCAGAATTAAAGAGTCTGTCTTTCATGGGGACAAATCTTTC

Downstream sequence

GACCCCTCCTTGCTAACCCACCTGTAACTATTTATgatcactcaaatagtaaatggaggggtaaagttcaaaagatggtctgcttgatgacaatgtccac

Target sequence

AGAAACATGCTTCCTTCCACTTTCCTCCAACCCAGGAACCGGCGCTATAAACCACCTGGTGCTCAAGCAGAAACGTGGGGGCTGTCCAT