Basic Information
VIS ID
TVIS10019318
Fusion event
HBV-chr7 integration
Validated
No
Detection method
VirusFinder
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Host Sequence
Chromosome
chr7
Cytoband
p13
Reference genome
GRCh37/hg19
Start
43915585/43875986 (Hg38)
End
43915585/43875986 (Hg38)
Location type
Intron3,Exon1
Fragile sites / regions
FRA7D
Target gene
URGCP ; URGCP-MRPS24
miRNAs that regulate target gene
hsa-mir-877-3p ; hsa-mir-484 ; hsa-mir-548s ; hsa-mir-3926 ; hsa-mir-769-5p ; hsa-mir-4786-5p ; hsa-mir-3120-5p ; hsa-mir-3190-5p ; hsa-mir-5699-3p ; hsa-mir-4421 ; hsa-mir-339-5p ; hsa-mir-6849-3p ; hsa-mir-10b-5p ; hsa-mir-10a-5p ; hsa-mir-595 ; hsa-mir-6732-3p ; hsa-mir-147a ; hsa-mir-6818-5p ; hsa-mir-644a ; hsa-mir-3911 ; hsa-mir-7847-3p ; hsa-mir-139-3p ; hsa-mir-549a ; hsa-mir-581 ; hsa-mir-1278 ; hsa-mir-7111-3p ; hsa-mir-6852-3p ; hsa-mir-3909 ; hsa-mir-3622b-5p ; hsa-mir-6820-5p ; hsa-mir-4734 ; hsa-mir-136-5p ; hsa-mir-4304 ; hsa-mir-6769b-3p ; hsa-mir-4723-3p ; hsa-mir-3183 ; hsa-mir-3664-3p ; hsa-mir-5000-3p ; hsa-mir-4436a
Nearest miRNA
hsa-mir-1183/Upstream/724992; hsa-mir-10399/Downstream/175780;
Nearest TSS
ENST00000635602/Upstream/6093; ENST00000454428/Downstream/5910;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/6107, chr7-CpG: 97/Downstream/29998
Upstream sequence
cgccatcaccaagtaccacagacaggtgtcggagatcaaggtatctatcagcagggttagtttcttctgggatctttcctcttgatttgcagataagcgt
Downstream sequence
ccctgccctcaaggagctcacagtctggggggacagacatgtaaacacatgagttacaacgcgctgcgtgaagtgtgtggcagaggtataacaaagtgct
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
Curate