Basic Information
VIS ID
TVIS10019320
Fusion event
HBV-KMT2C integration
Validated
No
Detection method
VirusFinder
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Host Sequence
Chromosome
chr7
Cytoband
q36.1
Reference genome
GRCh37/hg19
Start
151997549/152300464 (Hg38)
End
151997549/152300464 (Hg38)
Location type
Intron53
Fragile sites / regions
FRA7I
Target gene
KMT2C
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-128-3p ; hsa-mir-26b-5p ; hsa-mir-940 ; hsa-mir-708-5p ; hsa-mir-106b-3p ; hsa-mir-652-3p ; hsa-mir-615-3p ; hsa-mir-484 ; hsa-mir-320a ; hsa-mir-186-5p ; hsa-mir-15b-5p ; hsa-mir-196a-5p ; hsa-mir-610 ; hsa-mir-93-3p ; hsa-mir-4663 ; hsa-mir-4632-3p ; hsa-mir-6746-3p ; hsa-mir-27b-3p ; hsa-mir-27a-3p ; hsa-mir-934
Nearest miRNA
hsa-mir-10399/Upstream/866825; hsa-mir-153-2/Downstream/5273872;
Nearest TSS
ENST00000635602/Upstream/52445; ENST00000564834/Downstream/11832;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/168907, chr7-CpG: 31/Downstream/66285
Nearest cancer related gene
KMT2C(TSG, No orient, 0)
Upstream sequence
tccatatctatgtatttatcttgcagaagtagaaagatgtgtgcacaaggatattcatagcagtacagtgtaaaatagcaaaaaaaaaatggaggtaggt
Downstream sequence
gtcacatatgttgttgtattttcgttaagggggaaagaaggtagtctgtgtgatcctcatggaaggcacagcacataaggaagctggtacatggattttt
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
Curate