Basic Information
VIS ID
TVIS10019362
Fusion event
HBV-RAD51B integration
Validated
No
Detection method
VirusFinder
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Host Sequence
Chromosome
chr14
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
68422612/67955895 (Hg38)
End
68422612/67955895 (Hg38)
Location type
Intron7
Fragile sites / regions
FRA14C
Target gene
RAD51B
miRNAs that regulate target gene
hsa-mir-484 ; hsa-mir-4668-5p ; hsa-mir-2053 ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-30b-3p ; hsa-mir-3689a-3p ; hsa-mir-1273h-5p ; hsa-mir-569 ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-766-5p ; hsa-mir-6871-5p ; hsa-mir-4496 ; hsa-mir-4506
Nearest miRNA
hsa-mir-208a/Upstream/513965; hsa-mir-1185-1/Downstream/4560925;
Nearest TSS
ENST00000550708/Upstream/47590; ENST00000554575/Downstream/44384;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/280730, chr14-CpG: 40/Downstream/672403
Upstream sequence
aagtggataagtgttcccttttctccacagccttgccagatgatctgttggtgttcttttttttttttttaacttttgaataatcgcgattctgactggt
Downstream sequence
GCTTTTAGCAATGAAAATAGTGTGGGCAAAGATGGAACAGAGGTGGAGATGTAGGAGATATTTGGGAACATTCTTTCCCTAGTTCCTTTCCTGAAAGTAA
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
Curate