VISDB - VIS Detail

Expression analysis of TCGA samples

Basic Information

VIS ID

TVIS10019408

Fusion event

HBV-IGF2R integration

Validated

No

Detection method

VirusFinder

Data source

Curated

Sample type

Tumor

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2012

PubMed ID

22634754

Virus Sequence

Virus name

HBV

Reference genome

NC_003977

Host Sequence

Chromosome

chr6

Cytoband

q25.3

Reference genome

GRCh37/hg19

Start

160521754/160100722 (Hg38)

End

160521844/160100812 (Hg38)

Location type

Intron45

Target gene

IGF2R

miRNAs that regulate target gene

hsa-mir-16-5p ; hsa-mir-657 ; hsa-mir-155-5p ; hsa-mir-9-5p ; hsa-mir-26b-5p ; hsa-mir-1271-5p ; hsa-mir-423-3p ; hsa-mir-128-3p ; hsa-mir-211-5p ; hsa-mir-545-5p ; hsa-mir-412-3p ; hsa-mir-377-3p ; hsa-mir-218-5p ; hsa-mir-96-3p ; hsa-mir-2681-3p ; hsa-mir-548m ; hsa-mir-8485 ; hsa-mir-7977 ; hsa-mir-4284 ; hsa-mir-24-3p ; hsa-mir-564 ; hsa-mir-6860 ; hsa-mir-612 ; hsa-mir-5189-5p ; hsa-mir-3187-5p ; hsa-mir-1285-3p ; hsa-mir-383-3p ; hsa-mir-342-3p ; hsa-mir-6777-3p ; hsa-mir-6089 ; hsa-mir-561-5p ; hsa-mir-6715b-3p ; hsa-mir-4742-3p ; hsa-mir-6715a-3p ; hsa-mir-1178-5p ; hsa-mir-649 ; hsa-mir-106a-3p ; hsa-mir-1296-5p ; hsa-mir-6877-5p ; hsa-mir-4480 ; hsa-mir-5008-5p ; hsa-mir-3146 ; hsa-mir-454-3p ; hsa-mir-4295 ; hsa-mir-3666 ; hsa-mir-301b-3p ; hsa-mir-301a-3p ; hsa-mir-130b-3p ; hsa-mir-130a-3p ; hsa-mir-4512 ; hsa-mir-6895-5p ; hsa-mir-519c-3p ; hsa-mir-519b-3p ; hsa-mir-519a-3p ; hsa-mir-1247-3p ; hsa-mir-1827 ; hsa-mir-1910-3p ; hsa-mir-3612 ; hsa-mir-4537 ; hsa-mir-455-3p ; hsa-mir-4756-3p ; hsa-mir-5186 ; hsa-mir-5694 ; hsa-mir-6499-3p ; hsa-mir-650 ; hsa-mir-6511a-5p ; hsa-mir-6516-5p ; hsa-mir-4252 ; hsa-mir-4719 ; hsa-mir-551b-5p

Nearest miRNA

hsa-mir-10398/Upstream/1335969; hsa-mir-1913/Downstream/6408542;

Nearest TSS

ENST00000381078/Upstream/4275; ENST00000540443/Downstream/20977;

Nearest CpG islands

None/Target, chr6-CpG: 120/Upstream/9289, chr6-CpG: 55/Downstream/32817

Nearest cancer related gene

IGF2R(TSG, No orient, 0)

Upstream sequence

TAACTTCTGAAATACACACTAGAACCATTCAAAAAAAAATGGAAGTTTCTACAGTATTTGAGGTTGTCCTGCCAAGTTATAATTAATTCATGATCAATAA

Downstream sequence

cagagacttgctcttttgcccaggctggagtgcagtggtgcgatcttggctcactgcaacctctgcttcccagattcaagtgattctcatgcctcagcct

Target sequence

cctttttttttttttttttttttttttttttttttttttttttttttttttttttttttttttttttttttttttttttttttttggaga

Reference

Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.