CYP3A4 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10019432
Fusion event
HBV-CYP3A4 integration
Validated
No
Detection method
VirusFinder
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Host Sequence
Chromosome
chr7
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
99381633/99784010 (Hg38)
End
99381855/99784232 (Hg38)
Location type
Exon13
Fragile sites / regions
FRA7F
Target gene
CYP3A4
miRNAs that regulate target gene
hsa-mir-27b-3p
Nearest miRNA
hsa-mir-10525/Upstream/374746; hsa-mir-10399/Downstream/309328;
Nearest TSS
ENST00000635602/Upstream/3957; ENST00000631161/Downstream/33;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/166748, chr7-CpG: 76/Downstream/134747
Upstream sequence
cattatggtttttgccatgatttttaatgcaaaaaGGATTCAGGCAGGCATAGTCCTTTACCTGCATTAGAGATCATCTCATGAGTCTAGGCTTATTCTA
Downstream sequence
GCTGGAGCTGCAGCCAGTAGCAGGGCCACCTGTGCTCTGCCTGCAGTTGGAAGAGGCTTCTCCACCTTGGAAGTTGGCAAAGAATCACACACACACCACT
Target sequence
AGATAGAGGAGCACCAGGCTGACAGCCAGGAGAAGCCAGGTTTCCATGGCCAAGTCTGGGATGAGAGCCATCACTACTTTCCTTACTTATCTCTCTCCTCTGAGTCTTCCTTTCAGCTCTGTGTTGCTCTTTGCTGGGCTATGTGCATGGAGCTTTCCTGCCCTGCACAGCAGTGATTCAGTGAGGCTGTTGGATTGTTTATATGCTAGAGAAGGAGGCAGG
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
Curate