Basic Information
VIS ID
TVIS10019509
Fusion event
HBV-CENPU integration
Validated
No
Detection method
VirusFinder
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Host Sequence
Chromosome
chr4
Cytoband
q35.1
Reference genome
GRCh37/hg19
Start
185638289/184717135 (Hg38)
End
185638351/184717197 (Hg38)
Location type
Exon9
Target gene
CENPU
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-146b-5p ; hsa-mir-185-5p
Nearest miRNA
hsa-mir-12113/Upstream/2547757; hsa-mir-3945/Downstream/133816;
Nearest TSS
ENST00000502981/Upstream/3194; ENST00000508020/Downstream/16217;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/67309, chr4-CpG: 77/Downstream/16154
Upstream sequence
TATTAGAtggaaatagccttggatttggagtcacagtgcctgcagtcaggtcctggcttctccataaactctattttttgaaaaacctgattttctgaac
Downstream sequence
TGTAAAAAGTACAAGCCATCAATATCTTGTACACATTCCATTTATATTCACATGTCTTCTCTAACTTGCTCATTCAACATGAAAACAGACTCAATTTAAT
Target sequence
CTTTTTTGCACTAATTTTTACAGATTCGATTTCACTTGCTTCATTTCCAGAAGTGTCTGAAC
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
Curate