Basic Information
VIS ID
TVIS10019565
Fusion event
HBV-SPECC1 integration
Validated
No
Detection method
VirusFinder
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Host Sequence
Chromosome
chr17
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
20093762/20190449 (Hg38)
End
20093762/20190449 (Hg38)
Location type
Intron3
Target gene
SPECC1
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-186-5p ; hsa-mir-10a-5p ; hsa-mir-3613-3p ; hsa-mir-3976 ; hsa-mir-5007-5p ; hsa-mir-4717-3p ; hsa-mir-6871-5p ; hsa-mir-449b-3p ; hsa-mir-5698 ; hsa-mir-377-3p ; hsa-mir-143-5p ; hsa-mir-4430 ; hsa-mir-3652 ; hsa-mir-122-5p ; hsa-mir-504-3p ; hsa-mir-3135b ; hsa-mir-6847-3p ; hsa-mir-6499-3p ; hsa-mir-103b ; hsa-mir-4438 ; hsa-mir-6768-5p
Nearest miRNA
hsa-mir-1180/Upstream/845875; hsa-mir-10226/Downstream/7103461;
Nearest TSS
ENST00000595228/Upstream/5367; ENST00000584527/Downstream/15087;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/33702, chr17-CpG: 95/Downstream/129987
Upstream sequence
gattaaccattagctatttatataatcttttgtgagtaaactttcatcttagtttcaagtttatcacatgaaaaataggtgaattTTGGTCCATTTGGCT
Downstream sequence
acactttATTATGCTTTTACTGCCTTCTAAAAaaataaacactcttttttaaagagcagttttaggcacagcaaaattgagtgaaaagtacaagttttcc
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
Curate