Basic Information
VIS ID
TVIS10019568
Fusion event
HBV-FAM222B integration
Validated
No
Detection method
VirusFinder
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Host Sequence
Chromosome
chr17
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
27145817/28818799 (Hg38)
End
27145906/28818888 (Hg38)
Location type
Intron2
Target gene
FAM222B
miRNAs that regulate target gene
hsa-mir-106b-5p ; hsa-mir-181a-5p ; hsa-mir-142-3p ; hsa-mir-3678-3p ; hsa-mir-6727-5p ; hsa-mir-5010-5p ; hsa-mir-4525 ; hsa-mir-2467-3p ; hsa-mir-202-3p ; hsa-mir-4462 ; hsa-mir-6730-5p ; hsa-mir-3158-5p ; hsa-mir-4787-5p ; hsa-mir-759 ; hsa-mir-3677-5p ; hsa-mir-6831-5p ; hsa-mir-3927-3p ; hsa-mir-488-3p ; hsa-mir-4500 ; hsa-let-7b-5p ; hsa-let-7a-5p ; hsa-let-7e-5p ; hsa-let-7f-5p ; hsa-let-7c-5p ; hsa-let-7g-5p ; hsa-let-7i-5p ; hsa-mir-4458 ; hsa-mir-98-5p ; hsa-let-7d-5p ; hsa-mir-379-5p ; hsa-mir-3529-5p ; hsa-mir-130a-5p ; hsa-mir-23c ; hsa-mir-23a-3p ; hsa-mir-23b-3p
Nearest miRNA
hsa-mir-1180/Upstream/458065; hsa-mir-10226/Downstream/42481;
Nearest TSS
ENST00000595228/Upstream/6364; ENST00000578001/Downstream/23839;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/74247, chr17-CpG: 21/Downstream/23620
Upstream sequence
ctggaggttattatgttaagttaaataagccaggcatagaaagacaaagatcagtgttctcactgatatgtaggagctaaaaaagttgctctcgtggaga
Downstream sequence
GCATCTTTAAATGCACAGCCAATTCCCTTCTAGTGCCAAAGCCAATGGCTTCTCCTGTAGATAAAATGGCACGGTTCCTGAAAAAGCCCTGGACGCTGTT
Target sequence
GGTAGAAAAAGTAAAAAGCCAAAATCCTGAAAAAGTTTCACACACATAGACAAAATGAGACAGCAAACTTGTGAATCGAGCATGATTTG
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
Curate