Basic Information
VIS ID
TVIS10019625
Fusion event
HBV-chr3 integration
Validated
No
Detection method
VirusFinder
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28622513
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
1815
Integrated sequence
ACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACC| |ATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACC
Host Sequence
Chromosome
chr3
Cytoband
p12.3
Reference genome
GRCh37/hg19
Start
79479322/79430172 (Hg38)
End
79479322/79430172 (Hg38)
Location type
Intron
Target gene
LOC101927374 ; ROBO1
miRNAs that regulate target gene
hsa-mir-217 ; hsa-mir-218-5p ; hsa-mir-423-3p ; hsa-mir-25-3p ; hsa-mir-6835-3p ; hsa-mir-146a-5p ; hsa-mir-377-3p ; hsa-mir-1185-2-3p ; hsa-mir-876-3p ; hsa-mir-3591-5p ; hsa-mir-921 ; hsa-mir-3606-5p ; hsa-mir-524-5p ; hsa-mir-520d-5p ; hsa-mir-636 ; hsa-mir-3140-3p ; hsa-mir-4445-5p ; hsa-mir-508-3p ; hsa-mir-8062 ; hsa-mir-8079 ; hsa-mir-1245a ; hsa-mir-561-3p ; hsa-mir-548at-5p ; hsa-mir-548ay-3p ; hsa-mir-548at-3p ; hsa-mir-548as-3p ; hsa-mir-548t-3p ; hsa-mir-548ap-3p ; hsa-mir-548aa ; hsa-mir-299-5p ; hsa-mir-5590-3p ; hsa-mir-142-5p ; hsa-mir-4782-3p ; hsa-mir-6766-3p ; hsa-mir-219a-5p ; hsa-mir-6885-3p ; hsa-mir-1273e ; hsa-mir-4327 ; hsa-mir-1287-5p ; hsa-mir-3135b ; hsa-mir-330-3p ; hsa-mir-29a-3p ; hsa-mir-218-2-3p
Nearest miRNA
hsa-let-7g/Upstream/3691809; hsa-mir-12124/Downstream/77715;
Nearest TSS
ENST00000440867/Upstream/410713; ENST00000473938/Downstream/159770;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/410756, chr3-CpG: 29/Downstream/336316
Nearest cancer related gene
ROBO1(TSG, No orient, 0)
Upstream sequence
cctgacaGACACCaggcacaagaatgtaaaatcatttgccccagattgtatagctagaaaatgcagaactgggattGTTGCCTTTCTCTACCCCACTGTC
Downstream sequence
TAGGCCATGCAAGTTACAAAAACTGGTCTTTTGAAATATCTTAAACATGTAAGTGTAAGCAATATTTATAATTCGTAAATTTTCAGAAATTAAGTTCAAT
Reference
Cancer Genome Atlas Research Network. Electronic address, w. b. e. and N. Cancer Genome Atlas Research . Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma. Cell ,2017,169(7): 1327-1341 e13
Curate