TLE4 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10019654
Fusion event
HBV-TLE4 integration
Validated
No
Detection method
VirusFinder
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28622513
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
1589
End
1813
Integrated sequence
GCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCAC
Host Sequence
Chromosome
chr9
Cytoband
q21.31
Reference genome
GRCh37/hg19
Start
82327257/79712342 (Hg38)
End
82327257/79712342 (Hg38)
Location type
Intron12
Target gene
TLE4
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-548b-3p ; hsa-mir-335-5p ; hsa-mir-186-5p ; hsa-mir-103a-3p ; hsa-mir-26b-5p ; hsa-mir-16-5p ; hsa-let-7d-5p ; hsa-mir-193b-3p ; hsa-mir-221-3p ; hsa-mir-195-5p ; hsa-mir-15a-5p ; hsa-mir-15b-5p
Nearest miRNA
hsa-mir-101-2/Upstream/8902258; hsa-let-7a-1/Downstream/4257406;
Nearest TSS
ENST00000422679/Upstream/3749; ENST00000565707/Downstream/174336;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/138697, chr9-CpG: 255/Downstream/1974882
Upstream sequence
gagcacctgccttgagtgttacagatgagaagtacatggtaccaggagagtttggacaacagaaaacttttactggggaaatgatgactgatttacaatc
Downstream sequence
TAAAAATAAAACTTAAAATTAGCAGTGGATCCAACAGTGCTATGTATAAATTAGTTCGATGACAGTAGGCTGGTTATGTGTCCACCACATATGTGGATTC
Reference
Cancer Genome Atlas Research Network. Electronic address, w. b. e. and N. Cancer Genome Atlas Research . Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma. Cell ,2017,169(7): 1327-1341 e13
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