Basic Information
VIS ID
TVIS10019777
Fusion event
HBV-GCFC2 integration
Validated
No
Detection method
VirusFinder
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29212479
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
1739
Integrated sequence
TTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGG| |AGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTA
Host Sequence
Chromosome
chr2
Cytoband
p12
Reference genome
GRCh37.55
Start
75933416/75706290 (Hg38)
End
75933416/75706290 (Hg38)
Location type
Intron15
Fragile sites / regions
FRA2S
Target gene
GCFC2
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-155-5p ; hsa-mir-10a-3p ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-1273e ; hsa-mir-6807-5p ; hsa-mir-6778-5p ; hsa-mir-1233-5p ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-2467-3p ; hsa-mir-6894-5p ; hsa-mir-1233-3p ; hsa-mir-1225-3p ; hsa-mir-605-3p ; hsa-mir-6511a-5p ; hsa-mir-1910-3p ; hsa-mir-3714 ; hsa-mir-1252-5p ; hsa-mir-150-3p ; hsa-mir-4762-3p ; hsa-mir-514a-3p ; hsa-mir-514b-3p ; hsa-mir-532-5p ; hsa-mir-5589-3p ; hsa-mir-5683
Nearest miRNA
hsa-mir-1285-2/Upstream/615376; hsa-mir-10b/Downstream/3943004;
Nearest TSS
ENST00000437798/Upstream/4918; ENST00000603612/Downstream/4316;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/58996, chr2-CpG: 64/Downstream/4241
Upstream sequence
TACAAGATTACAGAACTGTACCTAATTCCTATTACTGTGTTTCAAAGAAACACGTTTTGTAAGGTTTTTAAAATAATTCTGATAAAATGTTAAGGTGTTC
Downstream sequence
aagaatacaggctccagaacaaactgggtttgaatcctagccctgctacttataagctgtctgacctgtgcatgttaAAATGTAATAAAAATGAGCAATT
Reference
Yoo, S., et al. A pilot systematic genomic comparison of recurrence risks of hepatitis B virus-associated hepatocellular carcinoma with low- and high-degree liver fibrosis. BMC Med ,2017, 15(1): 214.
Curate