Basic Information
VIS ID
TVIS10019803
Fusion event
HBV-chr2 integration
Validated
No
Detection method
VirusFinder
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29212479
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
1754
Integrated sequence
CATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGA| |TTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCA
Host Sequence
Chromosome
chr2
Cytoband
q22.1
Reference genome
GRCh37.55
Start
138944676/138187106 (Hg38)
End
138944676/138187106 (Hg38)
Fragile sites / regions
FRA2S
Nearest miRNA
hsa-mir-128-1/Upstream/2521628; hsa-mir-10b/Downstream/2399520;
Nearest TSS
ENST00000437798/Upstream/85222; ENST00000412593/Downstream/283550;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/1420980, chr2-CpG: 71/Downstream/314357
Nearby gene
HNMT
Upstream sequence
ATATAAGTAATATACTTCAAGGCACTAGAAAAACTAAATAAGTAAAGCCTGATAAAAAGAAAAACATAGCTAAAGAGTTGGGCCTATTAAAAATATACTC
Downstream sequence
TTGGTAACTTTCAGCCCAGCCACGTGCACCACTCCATTCCTGGATGCACTTGCTCCCAGAGCATCTCTGAATGCATACCTCCTCTCTGCTCTCCATTTCC
Reference
Yoo, S., et al. A pilot systematic genomic comparison of recurrence risks of hepatitis B virus-associated hepatocellular carcinoma with low- and high-degree liver fibrosis. BMC Med ,2017, 15(1): 214.
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