PPP2R2B _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10019811
Fusion event
HBV-PPP2R2B integration
Validated
No
Detection method
VirusFinder
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29212479
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
1991
Integrated sequence
GGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCT| |TCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGG
Host Sequence
Chromosome
chr5
Cytoband
q32
Reference genome
GRCh37.55
Start
146039378/146659815 (Hg38)
End
146039378/146659815 (Hg38)
Location type
Intron5
Target gene
PPP2R2B
miRNAs that regulate target gene
hsa-mir-30e-3p ; hsa-mir-6825-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-765 ; hsa-mir-6804-5p ; hsa-mir-665 ; hsa-mir-4779 ; hsa-mir-4459 ; hsa-mir-548t-3p ; hsa-mir-548ap-3p ; hsa-mir-548aa
Nearest miRNA
hsa-mir-10397/Upstream/2979844; hsa-mir-103a-1/Downstream/2402498;
Nearest TSS
ENST00000502646/Upstream/59439; ENST00000503975/Downstream/218766;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/211948, chr5-CpG: 97/Downstream/217968
Upstream sequence
ggagttcgagaccagcctggccaacatggagaaacctcgtctctactaaaattacaaaaattagtcagcatggtggtgggcgcctataattccagctact
Downstream sequence
TATTATTAGCATTCTTACCATTAACTTCCAATTGTAGAAAAATGGTCCATTCTGAAAGATTGCTTGGGGAAGATTTTCTGACTTTTCTATATTGACTATG
Reference
Yoo, S., et al. A pilot systematic genomic comparison of recurrence risks of hepatitis B virus-associated hepatocellular carcinoma with low- and high-degree liver fibrosis. BMC Med ,2017, 15(1): 214.
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