VISDB Viral Integration Site DataBase

VIS ID

TVIS10019916

Fusion event

HBV-RB1CC1 integration

Validated

No

Detection method

VirusFinder

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2016

PubMed ID

Virus name

HBV

Reference genome

Start

1744

Integrated sequence

CAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTG| |GGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCAT

Chromosome

chr8

Cytoband

q11.23

Reference genome

Start

End

53617387/52704827 (Hg38)

Location type

Intron23

Target gene

miRNAs that regulate target gene

hsa-mir-133b ; hsa-mir-375 ; hsa-mir-98-5p ; hsa-mir-193b-3p ; hsa-mir-20a-5p ; hsa-mir-20b-5p ; hsa-mir-224-3p

Nearest miRNA

hsa-mir-124-1/Upstream/9808551; hsa-mir-10400/Downstream/9009961;

Nearest TSS

Nearest CpG islands

None/Target, chr8-CpG: 109/Upstream/138759, chr8-CpG: 153/Downstream/8618

Nearest cancer related gene

RB1CC1(TSG, No orient, 0)

Upstream sequence

CCCTCCCTTTTCTGTTTCTCTTAGTACTCAACAATTTCATGATTAGTTAAAAACGGGTATTTATCCCATCCCCCATTTAAACATTGCCAAGTATTTTTCA

Downstream sequence

ATAAGTATTACTTTTCACCAAATAGTCACGATTTCCTAAAATCTGACTTGATGCTCATTTTATATAAAGTCCTTCTTAACTTTTATAAAATGAAACCATA

Target sequence

C