Basic Information
VIS ID
TVIS10019922
Fusion event
HBV-FYB2 integration
Validated
No
Detection method
VirusFinder
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
27064257
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
1154
End
1481
Integrated sequence
GCCCGGCAACGGCCAGGTCTGTGCCAAGTGTTTGCTGACGCAACCCCCACTGGCTGGGGCTTGGTCATGGGCCATCAGCGCATGCGTGGAACCTTTTCGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCCGCTTGTTTTGCTCGCAGCAGGTCTGGAGCAAACATTATCGGGACTGATAACTCTGTTGTCCTATCCCGCAAATATACATCGTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTG
Host Sequence
Chromosome
chr1
Cytoband
p32.2
Reference genome
GRCh37/hg19
Start
57257047/56791374 (Hg38)
End
57257047/56791374 (Hg38)
Location type
Intron18
Fragile sites / regions
FRA1B
Target gene
FYB2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-148b-3p
Nearest miRNA
hsa-mir-12136/Upstream/1565651; hsa-mir-101-1/Downstream/2941853;
Nearest TSS
ENST00000473358/Upstream/29361; ENST00000361249/Downstream/27997;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/145810, chr1-CpG: 222/Downstream/630917
Upstream sequence
tagggttagggttagggttagggttagggttgggttagggttagggttagggttagggttaggggttagggttaggggttagggttggggttggggttgg
Downstream sequence
ggttggggttggggttggggttggggttagggttagggttagggttagggttagggttagggttagggttagggttagggtgttagggtgttagggtgtt
Reference
Fujimoto, A., et al. Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer. Nat Genet ,2016,48(5): 500-509.
Curate