VISDB Viral Integration Site DataBase

VIS ID

TVIS10019939

Fusion event

HBV-POU2F3 integration

Validated

No

Detection method

RNA-Seq

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2013

PubMed ID

Virus name

HBV

Reference genome

Chromosome

chr11

Cytoband

q23.3

Reference genome

Start

End

120176931/120306222 (Hg38)

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-26b-5p ; hsa-mir-3620-5p ; hsa-mir-1587 ; hsa-mir-7703 ; hsa-mir-6720-5p ; hsa-mir-6512-3p ; hsa-mir-4741 ; hsa-mir-4675 ; hsa-mir-762 ; hsa-mir-5001-5p ; hsa-mir-4498 ; hsa-mir-4492 ; hsa-mir-6829-5p ; hsa-mir-4656 ; hsa-mir-4430 ; hsa-mir-3652 ; hsa-mir-6081 ; hsa-mir-3135b ; hsa-mir-661 ; hsa-mir-378g ; hsa-mir-766-3p ; hsa-mir-939-3p ; hsa-mir-6849-3p ; hsa-mir-508-5p ; hsa-mir-3679-3p ; hsa-mir-5681b ; hsa-mir-6832-3p ; hsa-mir-4252 ; hsa-mir-4793-3p ; hsa-mir-1273g-3p ; hsa-mir-7977 ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-4755-3p ; hsa-mir-342-3p ; hsa-mir-1972 ; hsa-mir-5685 ; hsa-mir-4690-3p ; hsa-mir-1228-3p ; hsa-mir-5694 ; hsa-mir-3675-3p ; hsa-mir-4293 ; hsa-mir-4433a-3p ; hsa-mir-4459 ; hsa-mir-4684-5p ; hsa-mir-4768-3p ; hsa-mir-548c-3p ; hsa-mir-6771-3p

Nearest miRNA

hsa-mir-10392/Upstream/993077; hsa-let-7a-2/Downstream/1793535;

Nearest TSS

Nearest CpG islands

None/Target, chr11-CpG: 30/Upstream/65910, chr11-CpG: 68/Downstream/18874

Nearest cancer related gene

POU2F3(TSG, No orient, 0)

Upstream sequence

gtatgtgtcatattggtgttttttcttccttgtatgtttgatagacttttccagtgaagacatttgcacctagagctttctttatgtgatggggttttga

Downstream sequence

GTAGTTCTTGAGGAGGTTTTCAGCAGACAGGGACTTACTGCAACCCATGCTGGTCAGGAAAGCCTGACAGCAGGAATGGGGTTTGCAGGAGGACTCAGTG

Target sequence

TGGATCTGCAGAGCAGATACACTTATGCAGATTGCTGTCTGGAATAAGTCTAGTCAGGGATACAGGGCAGTGGGGCCTCTAGGGTCTCACTGGGAGGGGGAGACCACAGGCACGACACAGGGTCTTTCCCTGG