VISDB Viral Integration Site DataBase

VIS ID

TVIS10019970

Fusion event

HBV-GLI2 integration

Validated

No

Detection method

RNA-Seq

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2013

PubMed ID

Virus name

HBV

Reference genome

Chromosome

chr2

Cytoband

q14.2

Reference genome

Start

End

121709022/120951446 (Hg38)

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-1-3p ; hsa-mir-26b-5p ; hsa-mir-31-5p ; hsa-mir-218-5p ; hsa-mir-574-5p ; hsa-mir-5572 ; hsa-mir-4260 ; hsa-mir-450a-2-3p ; hsa-mir-6855-5p ; hsa-mir-3170 ; hsa-mir-6819-5p ; hsa-mir-6812-5p ; hsa-mir-6737-5p ; hsa-mir-6740-5p ; hsa-mir-6867-5p ; hsa-mir-3650 ; hsa-mir-4455 ; hsa-mir-6747-5p ; hsa-mir-608 ; hsa-mir-4651 ; hsa-mir-4664-5p ; hsa-mir-342-5p ; hsa-mir-4748 ; hsa-mir-4464 ; hsa-mir-466 ; hsa-mir-6793-3p ; hsa-mir-4643 ; hsa-mir-4789-3p ; hsa-mir-95-5p ; hsa-mir-223-5p ; hsa-mir-541-3p ; hsa-mir-654-5p ; hsa-mir-6769a-5p ; hsa-mir-6769b-5p ; hsa-mir-92a-2-5p

Nearest miRNA

hsa-mir-1285-2/Upstream/7229873; hsa-mir-10b/Downstream/6472091;

Nearest TSS

Nearest CpG islands

None/Target, chr2-CpG: 135/Upstream/83607, chr2-CpG: 22/Downstream/33084

Nearest cancer related gene

GLI2(OG, No orient, 0)

Upstream sequence

TTTTGACATTTCTTCAGGTGGCAAATATTACAACAGACAAAAATATACCACAGAAGATCCCAGGAAATAACATATTGGTGCTTCTCTCTTTTCATTCCTA

Downstream sequence

TGAGTAGGGTGTGGGGATGGGGAGGGGCAGCTAGGGCACTGGGGCAGGGCGCAGCCAGCCTCTCTCACGCTAACACTGTCAACTCCTCAGCCTTGGTCCC

Target sequence

GGCCCCCTGCCCTCAGCGGCAGCCCTGTCATCTCTGACATCTCCTTGATCCGGCTTTCCCCGCACCCGGCTGGCCCTGGGGAGTCCCCCTTCAACGCCCCCCACCCGTACGTGAACCCCCACATGGAGCACTACCTCCGTTCTGTGCACAGCAGCCCCACGCTCTCCATGATCTCTGCAGCCAGGGGCCTCAGCCCCGCTGATGG