Basic Information
VIS ID
TVIS10020125
Fusion event
HBV-chr13 integration
Validated
No
Detection method
VirusScan
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2016
PubMed ID
27339696
Virus Sequence
Virus name
HBV
Reference genome
NC_003977.1
Start
2346
End
3446
Orient
+
Integrated sequence
TAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATCCCTTGGACTCATAAGGTGGGAAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTGATTGGAAAACTCCCTCCTTTCCTCACATTCATTTACAGGAGGACATTATTAATAGATGTCAACAATATGTGGGCCCTCTGACAGTTAATGAAAAAAGGAGATTAAAATTAATTATGCCTGCTAGGTTCTATCCTAACCTTACCAAATATTTGCCCTTGGACAAAGGCATTAAACCGTATTATCCTGAATATGCAGTTAATCATTACTTCAAAACTAGGCATTATTTACATACTCTGTGGAAGGCTGGCATTCTATATAAGAGAGAAACTACACGCAGCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGAGCTACAGCATGGGAGGTTGGTCTTCCAAACCTCGACAAGGCATGGGGACGAATCTTTCTGTTCCCAATCCTCTGGGATTCTTTCCCGATCACCAGTTGGACCCTGCGTTCGGAGCCAACTCAAACAATCCAGATTGGGACTTCAACCCCAACAAGGATCACTGGCCAGAGGCAAATCAGGTAGGAGCGGGAGCATTTGGTCCAGGGTTCACCCCACCACACGGAGGCCTTTTGGGGTGGAGCCCTCAGGCTCAGGGCATATTGACAACACTGCCAGCAGCACCTCCTCCTGCCTCCACCAATCGGCAGTCAGGAAGACAGCCTACTCCCATCTCTCCACCTCTAAGAGACAGTCATCCTCAGGCCATGCAGTGGAA
Host Sequence
Chromosome
chr13
Cytoband
q32.1
Reference genome
GRCh37/hg19
Start
96229677/95577423 (Hg38)
End
96230727/95578473 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA13D
Target gene
CLDN10 ; DZIP1
miRNAs that regulate target gene
hsa-let-7b-5p ; hsa-mir-124-3p ; hsa-mir-99b-3p ; hsa-let-7e-5p ; hsa-mir-331-3p ; hsa-mir-6810-3p ; hsa-mir-6801-3p ; hsa-mir-6729-3p ; hsa-mir-4756-3p ; hsa-mir-3919 ; hsa-mir-3925-5p ; hsa-mir-486-5p
Nearest miRNA
hsa-mir-1297/Upstream/3087203; hsa-mir-1267/Downstream/848756;
Nearest TSS
ENST00000623511/Upstream/17273; ENST00000376795/Downstream/9201;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/24181, chr13-CpG: 89/Downstream/62879
Upstream sequence
CACTGTTCATACCTTTGTTTCGTGGCCTTCCCAGGGGAAGTACTGTCTTGTTTATCTTTGCATCTGCTCCTGCTGCGGTCATCGGCAGAGCACTGTCACC
Downstream sequence
GGCTGCACACAGGCAAATTCTAGTTTGTTTTTTTTAAGTATTCTACAACATTTATTTAAAAAGGTAAATCTTTTTGTTGAAGCAGCAAGTTATCTGGTAG
Target sequence
TATGATTCTTAGAAACTTCCAAAATCCGGAATTGGAAAAGGTTAGCAGTACAGTTAATTTTTTAAAGTTTTACCATTACTATATTCCAAAGAAAATTCTAACGTAGAAATAAGGGTCTGAATATGAGGACATGTTCTTCACGTTGGCCTCATCATAATTTTCCTCTAGGTAGGCAGGAATGTTGATGGCCTCTACTAAGTCTCCTAGCTTCCAGGAGGGTGAGTTTTAAAACATGGTTTTGTAAGAGGATAACTG
Reference
Cao, S., et al.Divergent viral presentation among human tumors and adjacent normal tissues. Sci Rep,2016, 6: 28294.
Curate