VISDB Viral Integration Site DataBase

VIS ID

TVIS10020133

Fusion event

HBV-KCNH1 integration

Validated

No

Detection method

VirusScan

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2016

PubMed ID

Virus name

HBV

Reference genome

Start

140

End

1240

Orient

+

Integrated sequence

ACCCTGCACCGAACATGGAGAGCACAACATCAGGATTCCTAGGACCCCTGCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCACAGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGAGCACCCACGTGTCCTGGCCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAACTTGTCCTGGCTATCGCTGGATGTGTCTGCGGCGTTTTA

Chromosome

chr1

Cytoband

q32.2

Reference genome

Start

End

210977913/210804571 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-296-3p ; hsa-mir-335-5p ; hsa-mir-34a-5p ; hsa-mir-7704 ; hsa-mir-615-5p ; hsa-mir-2467-3p ; hsa-mir-4257 ; hsa-mir-6890-5p ; hsa-mir-7843-5p ; hsa-mir-6879-5p ; hsa-mir-6735-5p ; hsa-mir-4632-5p ; hsa-mir-4436b-3p ; hsa-mir-6753-5p ; hsa-mir-1911-3p ; hsa-mir-525-5p ; hsa-mir-520a-5p ; hsa-mir-505-3p ; hsa-mir-4290 ; hsa-mir-1233-3p ; hsa-mir-7113-3p ; hsa-mir-4673 ; hsa-mir-339-5p ; hsa-mir-4645-5p ; hsa-mir-6715b-5p ; hsa-mir-4269 ; hsa-mir-4687-5p ; hsa-mir-508-5p

Nearest miRNA

hsa-mir-101-1/Upstream/1180011; hsa-mir-1182/Downstream/1273042;

Nearest TSS

Nearest CpG islands

None/Target, chr1-CpG: 111/Upstream/119601, chr1-CpG: 92/Downstream/328754

Upstream sequence

aagggagtgtctgggttaagatcggggatgaggagaccaaggttcttaatatgcagatgagtcttatcaagcttcagagaaaatagattgcaaatgtttc

Downstream sequence

CACACCAGTCAAAATCCAAACCCATCAGTGAATGAGCtttatcaagctctgctacgtgccaagcactgtgctacctgccaaggacaggatggtgaataaa

Target sequence

ttctaaggttaatgcaaaaaaatccatgatgaacaaaatatcaaaagtttgaataaagacaagatcagtaacagtgctgtgctatcttcaagtctgggtaaaaagaaaattgacaatactgatctcccgtctctagtcatggctctgattcttatcatcatCCAAGTTTGGGAAATTCTACCCTGGACAGTTAGACTTCCAGCTCCTCTCTTCTCCAGGAAATACACCCTGCCTTTCTAATTTCTTAATGATGTT