VISDB Viral Integration Site DataBase

VIS ID

TVIS10020136

Fusion event

HBV-PPWD1 integration

Validated

No

Detection method

VirusScan

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2016

PubMed ID

Virus name

HBV

Reference genome

Start

1181

End

2281

Orient

+

Integrated sequence

GTTTGCTGACGCAACCCCCACGGGTTGGGGCTTGGCCATAGGCCATCGGCGCATGCGTGGAACCTTTGTGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCAGCTTGTTTTGCTCGCAGCCGGTCTGGAGCGAAACTTATCGGAACCGACAACTCAGTTGTCCTCTCTCGGAAATACACCTCCTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTCTACGTCCCGTC

Chromosome

chr5

Cytoband

q12.3

Reference genome

Start

End

64879049/65583222 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-361-3p ; hsa-mir-7153-5p ; hsa-mir-7641 ; hsa-mir-146b-5p ; hsa-mir-146a-5p ; hsa-mir-589-5p ; hsa-mir-4502 ; hsa-mir-4699-3p ; hsa-mir-4773 ; hsa-mir-4662a-5p ; hsa-mir-143-5p ; hsa-mir-3944-5p ; hsa-mir-548ax ; hsa-mir-548ao-5p ; hsa-mir-3622b-3p ; hsa-mir-3622a-3p ; hsa-mir-8066 ; hsa-mir-6768-3p ; hsa-mir-606 ; hsa-mir-340-5p ; hsa-mir-4423-3p ; hsa-mir-4775 ; hsa-mir-5590-3p ; hsa-mir-142-5p ; hsa-mir-3622a-5p ; hsa-mir-5582-5p ; hsa-mir-32-3p ; hsa-mir-561-3p ; hsa-mir-548at-5p ; hsa-mir-6875-3p ; hsa-mir-6883-3p ; hsa-mir-630 ; hsa-mir-4999-5p

Nearest miRNA

hsa-mir-10397/Upstream/5878469; hsa-mir-103a-1/Downstream/6586245;

Nearest TSS

Nearest CpG islands

None/Target, chr5-CpG: 87/Upstream/18716, chr5-CpG: 30/Downstream/40865

Upstream sequence

CACAGTCACCACACATCAGACCCCTGTGACCGATCACCATCCACAGTCACCACACATCAGACCCCACAACCGCCATCCACAGTCACCACACATCAGACCC

Downstream sequence

TGTATAACAACTGTTTTTATTGGCTTATGTAATTAAGAATGTAAATGTGTATATCTGAAGAAACCATGCAACTTAAAATTCCCGTTACTTTGACTTAAGG

Target sequence

TTACGTTCCCATAATTAAGTTACATCAGATAGAGGTTGCTTAGGAGAGAGCATTTCTACTTAAAGAAACAGGCCTTGAGAAGTCCAGAGTTTTAACAACTGAAAGGTTTTTCTCAATTCTTCCTAGACCCCAAGGATCTGAGATTTCTACAACTTCACTGAAAATTTGCATTCTTTCTCCTATGCTTCAGGGTTTAGATTCTAGGTCAGTTGGGACTGTGAAAAAAAATTAAGGATCCATTTCAGATTCATTTTT