VISDB Viral Integration Site DataBase

VIS ID

TVIS10020137

Fusion event

HBV-AKAP6 integration

Validated

No

Detection method

VirusScan

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2016

PubMed ID

Virus name

HBV

Reference genome

Start

1179

End

2279

Orient

+

Integrated sequence

GTGTTTGCTGACGCAACCCCCACGGGTTGGGGCTTGGCCATAGGCCATCGGCGCATGCGTGGAACCTTTGTGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCAGCTTGTTTTGCTCGCAGCCGGTCTGGAGCGAAACTTATCGGAACCGACAACTCAGTTGTCCTCTCTCGGAAATACACCTCCTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTCTACGTCCCG

Chromosome

chr14

Cytoband

q12

Reference genome

Start

End

33302791/32833585 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-1257 ; hsa-mir-4687-3p ; hsa-mir-7974 ; hsa-mir-583 ; hsa-mir-1276 ; hsa-mir-4311 ; hsa-mir-1303 ; hsa-mir-5096 ; hsa-mir-3187-3p ; hsa-mir-4435 ; hsa-mir-588 ; hsa-mir-4701-5p ; hsa-mir-548s ; hsa-mir-7641 ; hsa-mir-197-3p ; hsa-mir-411-5p ; hsa-mir-6832-5p ; hsa-mir-193b-5p ; hsa-mir-4755-3p ; hsa-mir-4695-3p ; hsa-mir-4716-5p ; hsa-mir-4781-3p ; hsa-mir-4478 ; hsa-mir-4419b ; hsa-mir-3929 ; hsa-mir-483-5p

Nearest miRNA

hsa-mir-208a/Upstream/1817793; hsa-mir-1185-1/Downstream/4118724;

Nearest TSS

Nearest CpG islands

None/Target, chr14-CpG: 35/Upstream/628826, chr14-CpG: 168/Downstream/99303

Upstream sequence

CATATGTATGTTTATTATTAATATAATGATTATATCTTATAGTTGTATATGGTGTTTTTACTCTTTTGCCCTAATTTGTCAAGCCTCCCAGGTTCTTACC

Downstream sequence

TTGTGTTTGGTTCATCCGGACTAGGTTTCACCCATTCTATAATTCCTAGAAACAAACTAGATGAAAATATCAATGAAATGATCCAGGTCTGTCTTACAAG

Target sequence

tggaagaagaaaaatagcctcaatctcccaccccatgtaggcactacctccccaattacccttagaaaatgatcacaccaactctgcctacacacttccagtgatagtggctcattgtctgttaaggcaaactgttccactgttgggcatatctctttgttagaaagttctttcttaggttgctaaaatctgcctagtaccccgctaccctgttctgtcttatggagcagcccagattatctttactccctcttt