VISDB Viral Integration Site DataBase

VIS ID

TVIS10020141

Fusion event

HBV-POU2F3 integration

Validated

No

Detection method

VirusScan

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2016

PubMed ID

Virus name

HBV

Reference genome

Start

1156

End

2256

Orient

+

Integrated sequence

GGCAACGGTCAGGTCTCTGCCAAGTGTTTGCTGACGCAACCCCCACGGGTTGGGGCTTGGCCATAGGCCATCGGCGCATGCGTGGAACCTTTGTGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCAGCTTGTTTTGCTCGCAGCCGGTCTGGAGCGAAACTTATCGGAACCGACAACTCAGTTGTCCTCTCTCGGAAATACACCTCCTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCG

Chromosome

chr11

Cytoband

q23.3

Reference genome

Start

End

120177331/120306622 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-26b-5p ; hsa-mir-3620-5p ; hsa-mir-1587 ; hsa-mir-7703 ; hsa-mir-6720-5p ; hsa-mir-6512-3p ; hsa-mir-4741 ; hsa-mir-4675 ; hsa-mir-762 ; hsa-mir-5001-5p ; hsa-mir-4498 ; hsa-mir-4492 ; hsa-mir-6829-5p ; hsa-mir-4656 ; hsa-mir-4430 ; hsa-mir-3652 ; hsa-mir-6081 ; hsa-mir-3135b ; hsa-mir-661 ; hsa-mir-378g ; hsa-mir-766-3p ; hsa-mir-939-3p ; hsa-mir-6849-3p ; hsa-mir-508-5p ; hsa-mir-3679-3p ; hsa-mir-5681b ; hsa-mir-6832-3p ; hsa-mir-4252 ; hsa-mir-4793-3p ; hsa-mir-1273g-3p ; hsa-mir-7977 ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-4755-3p ; hsa-mir-342-3p ; hsa-mir-1972 ; hsa-mir-5685 ; hsa-mir-4690-3p ; hsa-mir-1228-3p ; hsa-mir-5694 ; hsa-mir-3675-3p ; hsa-mir-4293 ; hsa-mir-4433a-3p ; hsa-mir-4459 ; hsa-mir-4684-5p ; hsa-mir-4768-3p ; hsa-mir-548c-3p ; hsa-mir-6771-3p

Nearest miRNA

hsa-mir-10392/Upstream/992560; hsa-let-7a-2/Downstream/1793135;

Nearest TSS

Nearest CpG islands

None/Target, chr11-CpG: 30/Upstream/65393, chr11-CpG: 68/Downstream/18474

Nearest cancer related gene

POU2F3(TSG, No orient, 0)

Upstream sequence

aggctcagagtgttagcgctttgcccaaagtcacacTTGGTTGGAGGTCAGTTATGATTCTCCAGCTACTTGTCGGGGTTTGGGATTATCTTCCCCCTTG

Downstream sequence

gagaacTGCCGGCCTAGGCAGAGAGAGGGAGTGAGCCAGTCTCCAGGGCTGGGCTCTATTCAGTCGATTCATATGGATTCGTGGTTACACTGGAGAGGGA

Target sequence

CATGCAGGATGTGGGCAAACAAGAGGAGGAGGCTGCCTCTCATGTTCCTCCCCCTCGGTCCCCACGCTTAGGGAGATGTGGGGCTGGCGATGGGAAAGCTGTATGGCAACGACTTCAGCCAGACCACCATCTCACGATTTGAGGCCCTCAACCTGAGCTTCAAGAACATGTGCAAGCTCAAGCCCCTGCTGGAGAAGTGGCTGAATGATGCAGGTAGGCCTCGCAAACACGGATGCCAGGGGCCCTAGAGGGCTC