VISDB Viral Integration Site DataBase

VIS ID

TVIS10020146

Fusion event

HBV-MREG integration

Validated

No

Detection method

VirusScan

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2016

PubMed ID

Virus name

HBV

Reference genome

Start

1090

End

2190

Orient

+

Integrated sequence

TCACTTTCTCGCCAACTTACAAGGCCTTTCTGTGTAAACAATATCTAAACCTTTACCCCGTTGCCCGGCAACGGTCAGGTCTCTGCCAAGTGTTTGCTGACGCAACCCCCACGGGTTGGGGCTTGGCCATAGGCCATCGGCGCATGCGTGGAACCTTTGTGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCAGCTTGTTTTGCTCGCAGCCGGTCTGGAGCGAAACTTATCGGAACCGACAACTCAGTTG

Chromosome

chr2

Cytoband

q35

Reference genome

Start

End

216871745/216007022 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-375 ; hsa-mir-130b-3p ; hsa-mir-26b-5p ; hsa-mir-19b-3p ; hsa-mir-106a-3p ; hsa-mir-122-5p ; hsa-mir-1307-3p ; hsa-mir-130a-3p ; hsa-mir-144-5p ; hsa-mir-301a-3p ; hsa-mir-301b-3p ; hsa-mir-3135b ; hsa-mir-3652 ; hsa-mir-3666 ; hsa-mir-3925-5p ; hsa-mir-4295 ; hsa-mir-4430 ; hsa-mir-454-3p ; hsa-mir-4638-5p ; hsa-mir-4712-3p ; hsa-mir-488-5p ; hsa-mir-504-3p ; hsa-mir-589-5p ; hsa-mir-6812-3p ; hsa-mir-95-5p

Nearest miRNA

hsa-mir-10b/Upstream/2247813; hsa-mir-1244-1/Downstream/1893491;

Nearest TSS

Nearest CpG islands

None/Target, chr2-CpG: 135/Upstream/569835, chr2-CpG: 51/Downstream/6154

Upstream sequence

gcggtccctagagtcgtcagaatcgtagagacagaaagcagagttgtgattgccaggggccggagggaggaaggagtgaggagttcatgttgaatgggtg

Downstream sequence

TCTGCTCTTTCTATGGCATTGAAATCTACTAGCATATgaatcccagttcgaccacgtgtgcctctaagcaagttactgaagttctctgtgtctcagtctc

Target sequence

TATATAACTGTCACAAAACAAAGATTTATTAACCAGACTAAAATGACTTCAGGTGCTAACAGAATAAACTATTTTACCCAGCATTTAAGCAGAGTTTATACTTTTTAAACATAGGTGGTGTAGTGATAAAATCACTTCAAGAGTCTAGAGAATAAAAAGTTGCAAGAAACTCTCACATGATGTGTAGGAGAAAGAAATTTCATCTTCTCGGGAACTTCCAATGGCACTATGACTAATGCAAGTCACAAAAAGAGA