VISDB Viral Integration Site DataBase

VIS ID

TVIS10020148

Fusion event

HBV-ERC1 integration

Validated

No

Detection method

VirusScan

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2016

PubMed ID

Virus name

HBV

Reference genome

Start

1075

End

2175

Orient

+

Integrated sequence

AATCTAAGCAGGCTTTCACTTTCTCGCCAACTTACAAGGCCTTTCTGTGTAAACAATATCTAAACCTTTACCCCGTTGCCCGGCAACGGTCAGGTCTCTGCCAAGTGTTTGCTGACGCAACCCCCACGGGTTGGGGCTTGGCCATAGGCCATCGGCGCATGCGTGGAACCTTTGTGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCAGCTTGTTTTGCTCGCAGCCGGTCTGGAGCGAAACTTATCGGAA

Chromosome

chr12

Cytoband

p13.33

Reference genome

Start

End

1568538/1459372 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-let-7b-5p ; hsa-mir-335-5p ; hsa-mir-183-5p ; hsa-mir-26b-5p ; hsa-let-7d-5p ; hsa-mir-320b ; hsa-mir-1229-3p ; hsa-mir-320a ; hsa-mir-221-3p ; hsa-mir-27b-3p ; hsa-mir-27a-3p ; hsa-mir-513a-5p ; hsa-mir-4278 ; hsa-mir-7111-5p ; hsa-mir-6870-5p ; hsa-mir-5698 ; hsa-mir-4723-5p ; hsa-mir-939-5p ; hsa-mir-1343-5p ; hsa-mir-920 ; hsa-mir-6726-5p ; hsa-mir-5591-5p ; hsa-mir-4300 ; hsa-mir-8085 ; hsa-mir-6731-5p ; hsa-mir-4487 ; hsa-mir-4445-5p ; hsa-mir-6754-5p ; hsa-mir-342-3p ; hsa-mir-4441 ; hsa-mir-4270 ; hsa-mir-761 ; hsa-mir-3619-5p ; hsa-mir-214-3p ; hsa-mir-6732-5p ; hsa-mir-6805-5p ; hsa-mir-6794-5p ; hsa-mir-4716-3p ; hsa-mir-6760-5p ; hsa-mir-6510-5p ; hsa-mir-6873-5p ; hsa-mir-143-5p ; hsa-mir-6879-3p ; hsa-mir-3652 ; hsa-mir-4430 ; hsa-mir-122-5p ; hsa-mir-504-3p ; hsa-mir-3135b ; hsa-mir-6499-3p ; hsa-mir-4462 ; hsa-mir-6773-3p ; hsa-mir-4638-5p ; hsa-mir-1307-3p ; hsa-mir-5190 ; hsa-mir-500b-3p ; hsa-mir-1277-5p ; hsa-mir-190a-3p ; hsa-mir-5011-5p ; hsa-mir-1267 ; hsa-mir-203b-3p ; hsa-mir-3183 ; hsa-mir-3612 ; hsa-mir-4723-3p ; hsa-mir-5196-3p ; hsa-mir-650 ; hsa-mir-6769b-3p ; hsa-mir-6787-3p ; hsa-mir-7111-3p ; hsa-mir-7158-3p

Nearest miRNA

hsa-let-7i/Downstream/200943;

Nearest TSS

Nearest CpG islands

None/Target, chr12-CpG: 104/Upstream/466703, chr12-CpG: 238/Downstream/70495

Upstream sequence

gaagaagaaacatttcctgttttgctccatgttgtatctgcagggcccagaacagAATAAATGACTACATCTTATATTCAAAATAACCCACTGAACATAA

Downstream sequence

gggagaaatttctttcagatctctggactagaaaTAATCAatattctattgaataaaatagaaatctttgagtctgtgatggtataaagaagtgaatgaa

Target sequence

atattgaggatagtgtgtttgttattataggagataagagtaccagatatagaaagagtaaagacaaatcctatcgtattggattgtttttagaggtattgatatgaattcatggtttttaacagataaatagatttagatttctctgtgtgtatgtgtgtttatatatgtgtatatgtgtatgtatacacatatacacatgtatgtattttcttttttttttttttttgagatggagtttcgctcttgttgccc