VISDB Viral Integration Site DataBase

VIS ID

TVIS10020169

Fusion event

HBV-ZDHHC21 integration

Validated

No

Detection method

VirusScan

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2016

PubMed ID

Virus name

HBV

Reference genome

Start

1163

End

2259

Orient

+

Integrated sequence

GTCAGGTCTCTGCCAAGTGTTTGCTGACGCAACCCCCACGGGTTGGGGCTTGGCCATAGGCCATCGGCGCATGCGTGGAACCTTTGTGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCAGCTTGTTTTGCTCGCAGCCGGTCTGGAGCGAAACTTATCGGAACCGACAACTCAGTTGTCCTCTCTCGGAAATACACCTCCTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTC

Chromosome

chr9

Cytoband

p22.3

Reference genome

Start

End

14602272/14602274 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-6782-3p ; hsa-mir-888-5p ; hsa-mir-4680-5p ; hsa-mir-4662a-5p ; hsa-mir-562 ; hsa-mir-8054 ; hsa-mir-548l ; hsa-mir-548k ; hsa-mir-548av-5p ; hsa-mir-559 ; hsa-mir-548y ; hsa-mir-548w ; hsa-mir-548o-5p ; hsa-mir-548j-5p ; hsa-mir-548i ; hsa-mir-548h-5p ; hsa-mir-548d-5p ; hsa-mir-548c-5p ; hsa-mir-548bb-5p ; hsa-mir-548b-5p ; hsa-mir-548ay-5p ; hsa-mir-548au-5p ; hsa-mir-548as-5p ; hsa-mir-548ar-5p ; hsa-mir-548aq-5p ; hsa-mir-548ap-5p ; hsa-mir-548am-5p ; hsa-mir-548ak ; hsa-mir-548ae-5p ; hsa-mir-548ad-5p ; hsa-mir-548ab ; hsa-mir-548a-5p ; hsa-mir-744-3p ; hsa-mir-4639-5p ; hsa-mir-92b-3p ; hsa-mir-92a-3p ; hsa-mir-367-3p ; hsa-mir-363-3p ; hsa-mir-32-5p ; hsa-mir-25-3p ; hsa-mir-548c-3p ; hsa-mir-4539 ; hsa-mir-8485 ; hsa-mir-466 ; hsa-mir-4672 ; hsa-mir-3941 ; hsa-mir-4744 ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-550b-2-5p ; hsa-mir-550a-5p ; hsa-mir-550a-3-5p ; hsa-mir-1271-3p ; hsa-mir-8063 ; hsa-mir-6780b-3p ; hsa-mir-4668-3p ; hsa-mir-129-5p ; hsa-mir-6885-3p ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-1178-3p ; hsa-mir-6873-3p ; hsa-mir-6845-3p ; hsa-mir-6832-3p ; hsa-mir-6756-3p ; hsa-mir-3127-3p ; hsa-mir-5571-5p ; hsa-mir-4452 ; hsa-mir-4460 ; hsa-mir-6718-5p ; hsa-mir-140-5p ; hsa-mir-203b-5p

Nearest miRNA

hsa-mir-101-2/Upstream/8593322; hsa-let-7a-1/Downstream/3971032;

Nearest TSS

Nearest CpG islands

None/Target, chr9-CpG: 64/Upstream/251710, chr9-CpG: 56/Downstream/90758

Upstream sequence

ctttctttctttctttttttttttttggagatgggattttgctatgttgaccaggctggtcttgctctcctgtgctcaagcagtcttcttccttcctgag

Downstream sequence

acaggtcatttgaaataattcagtcaaatttaaaaaatgaagaaagcctacaatgacacaagggacctcataaagtgacaaagtattcgcatcttgggag

Target sequence

gagaaattttttgcaatctacccatctgacaaagagctaatatccacaatgtacaaggaatttaaaccaacttacaagaaaaaaacaaccccatcaaaaagtgtgcaaaggatatgaacaggcacttctcaaaagaagacattttgcagccaacagacacatgaaaaaaaggtcatcatcactggtcattagagaaatgcaaatcaaaacaacaatgagataccatctcatgccagttagaatgacaaccattaa