VISDB Viral Integration Site DataBase

VIS ID

TVIS10020175

Fusion event

HBV-FRK integration

Validated

No

Detection method

VirusScan

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2016

PubMed ID

Virus name

HBV

Reference genome

Start

1163

End

2259

Orient

+

Integrated sequence

GTCAGGTCTCTGCCAAGTGTTTGCTGACGCAACCCCCACGGGTTGGGGCTTGGCCATAGGCCATCGGCGCATGCGTGGAACCTTTGTGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCAGCTTGTTTTGCTCGCAGCCGGTCTGGAGCGAAACTTATCGGAACCGACAACTCAGTTGTCCTCTCTCGGAAATACACCTCCTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTC

Chromosome

chr6

Cytoband

q22.1

Reference genome

Start

End

116272515/115951352 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-6867-5p ; hsa-mir-5682 ; hsa-mir-9-3p ; hsa-mir-6832-5p ; hsa-mir-4732-5p ; hsa-mir-6499-3p ; hsa-mir-5584-5p ; hsa-mir-4519 ; hsa-mir-29c-3p ; hsa-mir-29b-3p ; hsa-mir-29a-3p ; hsa-mir-6873-5p ; hsa-mir-4302 ; hsa-mir-6871-3p ; hsa-mir-4422 ; hsa-mir-6835-3p ; hsa-mir-129-5p ; hsa-mir-3680-3p ; hsa-mir-557 ; hsa-mir-507 ; hsa-mir-450b-5p ; hsa-mir-6788-5p ; hsa-mir-30c-2-3p ; hsa-mir-30c-1-3p ; hsa-mir-8085 ; hsa-mir-6731-5p ; hsa-mir-4714-3p ; hsa-mir-6878-5p ; hsa-mir-6871-5p ; hsa-mir-4282 ; hsa-mir-1261 ; hsa-mir-151a-3p ; hsa-mir-891a-3p ; hsa-mir-3688-5p ; hsa-mir-4463 ; hsa-mir-4499 ; hsa-mir-1243 ; hsa-mir-186-5p ; hsa-mir-3133 ; hsa-mir-6892-5p ; hsa-mir-203a-3p ; hsa-mir-6730-5p ; hsa-mir-7843-5p ; hsa-mir-6879-5p ; hsa-mir-6735-5p ; hsa-mir-4632-5p ; hsa-mir-4436b-3p ; hsa-mir-3974 ; hsa-mir-3646 ; hsa-mir-8077 ; hsa-mir-7160-5p ; hsa-mir-4663 ; hsa-mir-6761-5p ; hsa-mir-7853-5p ; hsa-mir-105-5p ; hsa-mir-4728-3p ; hsa-mir-607 ; hsa-mir-4435 ; hsa-mir-488-3p ; hsa-mir-3671 ; hsa-mir-503-3p ; hsa-mir-31-5p ; hsa-mir-3922-3p ; hsa-mir-3176 ; hsa-mir-3190-5p ; hsa-mir-6837-5p ; hsa-mir-4685-5p ; hsa-mir-4692 ; hsa-mir-4514 ; hsa-mir-6715b-5p ; hsa-mir-4269 ; hsa-mir-4742-5p ; hsa-mir-4698 ; hsa-mir-8063 ; hsa-mir-3187-3p ; hsa-mir-4529-5p ; hsa-mir-5191 ; hsa-mir-6847-3p ; hsa-mir-490-5p ; hsa-mir-195-3p ; hsa-mir-16-2-3p ; hsa-mir-6876-5p ; hsa-mir-4476 ; hsa-mir-4662a-5p ; hsa-mir-103b ; hsa-mir-3688-3p ; hsa-mir-8076 ; hsa-mir-450a-1-3p ; hsa-mir-2110 ; hsa-mir-6883-3p ; hsa-mir-3147 ; hsa-mir-4425 ; hsa-mir-4694-5p ; hsa-mir-6780b-5p ; hsa-mir-4725-3p ; hsa-mir-4271 ; hsa-mir-6739-5p ; hsa-mir-6733-5p ; hsa-mir-3153 ; hsa-mir-4668-5p ; hsa-mir-711 ; hsa-mir-4738-3p ; hsa-mir-454-5p ; hsa-mir-3938 ; hsa-mir-3654 ; hsa-mir-4661-5p ; hsa-mir-541-5p ; hsa-mir-522-3p ; hsa-mir-224-3p ; hsa-mir-4694-3p ; hsa-mir-548f-3p ; hsa-mir-548e-3p ; hsa-mir-548az-3p ; hsa-mir-548ar-3p ; hsa-mir-548a-3p ; hsa-mir-1248 ; hsa-mir-1237-3p ; hsa-mir-4529-3p ; hsa-mir-7850-5p ; hsa-mir-4520-2-3p ; hsa-mir-384 ; hsa-mir-7975 ; hsa-mir-4520-3p ; hsa-mir-5571-3p ; hsa-mir-6877-3p ; hsa-mir-6819-3p

Nearest miRNA

hsa-mir-10398/Upstream/9166084; hsa-mir-1202/Downstream/3117695;

Nearest TSS

Nearest CpG islands

None/Target, chr6-CpG: 120/Upstream/1606609, chr6-CpG: 74/Downstream/149158

Nearest cancer related gene

FRK(TSG, No orient, 0)

Upstream sequence

gtaaaataaaaccataatgagataatactgcacatctgccacaatggataacatcttcaaaagattaacaattttaattggaaaaaaatattgggaagta

Downstream sequence

tatatgaagtaagtattgcaattattcttccccatttcatagGAATTCCTTTTACTCAAAGGAATAGGTAACAAGTTGTGTGACCTATAATAGATGTTCT

Target sequence

gaatctacagggaacttaaacaaatttacaagaaataaaaaccatcaaaaagtgggcaaaggatatgaacagacacttttcaaaagaagacattcatgcagtcaacaaatatatgaaaaaaagctcatcatcactagagaaatccaaaccaaaaccacaatgagatagcatgtcatgtcagttagaatgggatcattaaaaagtcaggaaacaacagatgctggagaggatgtggagaaagaggaatgcttttac