VISDB Viral Integration Site DataBase

VIS ID

TVIS10020179

Fusion event

HBV-KMT2B integration

Validated

No

Detection method

VirusScan

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2016

PubMed ID

Virus name

HBV

Reference genome

Start

1178

End

2278

Orient

+

Integrated sequence

AGTGTTTGCTGACGCAACCCCCACGGGTTGGGGCTTGGCCATAGGCCATCGGCGCATGCGTGGAACCTTTGTGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCAGCTTGTTTTGCTCGCAGCCGGTCTGGAGCGAAACTTATCGGAACCGACAACTCAGTTGTCCTCTCTCGGAAATACACCTCCTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTCTACGTCCC

Chromosome

chr19

Cytoband

q13.12

Reference genome

Start

End

36215310/35724409 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-7515 ; hsa-mir-302a-5p ; hsa-mir-3154 ; hsa-mir-6782-3p ; hsa-mir-519c-3p ; hsa-mir-519b-3p ; hsa-mir-519a-3p ; hsa-mir-5692a ; hsa-mir-548t-5p ; hsa-mir-548az-5p ; hsa-mir-526b-3p ; hsa-mir-519d-3p ; hsa-mir-93-5p ; hsa-mir-20a-5p ; hsa-mir-17-5p ; hsa-mir-106b-5p ; hsa-mir-106a-5p ; hsa-mir-20b-5p ; hsa-mir-153-3p ; hsa-mir-1224-3p ; hsa-mir-1294 ; hsa-mir-1914-3p ; hsa-mir-214-3p ; hsa-mir-31-5p ; hsa-mir-3184-5p ; hsa-mir-3619-5p ; hsa-mir-3689d ; hsa-mir-423-5p ; hsa-mir-4316 ; hsa-mir-4426 ; hsa-mir-4440 ; hsa-mir-4459 ; hsa-mir-4647 ; hsa-mir-4662b ; hsa-mir-4688 ; hsa-mir-4722-5p ; hsa-mir-5194 ; hsa-mir-6085 ; hsa-mir-6165 ; hsa-mir-6734-5p ; hsa-mir-6738-5p ; hsa-mir-6743-5p ; hsa-mir-6789-5p ; hsa-mir-6813-5p ; hsa-mir-6851-5p ; hsa-mir-761 ; hsa-mir-7704 ; hsa-mir-885-3p

Nearest miRNA

hsa-mir-10395/Upstream/377731; hsa-let-7e/Downstream/3685214;

Nearest TSS

Nearest CpG islands

chr19-CpG: 24/Target, None/Upstream, None/Downstream

Upstream sequence

ctccagaagaggcccagaatctaaccacttctctccacttccactgtctccattctgctccgagctaccgttactcctcacctgcatcactgcaggggcc

Downstream sequence

atcgtctgagcctgggagttcaaggctgcggtgggctatgggtcacgccactgcattccagtctgggcaacagagcgagaccctgcctcaaaaaacaaga

Target sequence

AGTGGGGTTGGCATTCTTGTGGAGAGCTTCCTCTCTTCCCCCAGACCACCAGTCCCCTACCCTGGTGACGTGCTGCTCCCCTCCCCAGATACCGGAAGTGTGACAAAATAGAGGCTCGGAAGATGGAACGACTGGCTAAAAAAGGTGACGAGCTTTAAGGAGCATTTCTTCTCAAAACCGTGTTAGAGTTTGTGCTGTGGAGGGAGCTGTTTTTCTTTGCTCTCCTCCCTTGCAGCTCACCCTCTCCATCTTCTC