VISDB Viral Integration Site DataBase

VIS ID

TVIS10020193

Fusion event

HBV-TERT integration

Validated

No

Detection method

VirusScan

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2016

PubMed ID

Virus name

HBV

Reference genome

Start

1794

End

2890

Orient

+

Integrated sequence

TGGTCTGTTCACCAGCACCATGCAACTTTTTCCCCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATTTGGAGCTTCTGTGGAGTTACTCTCTTTTTTGCCTTCTGACTTCTTTCCTTCTATTCGAGATCTCCTCGACACCGCCTCTGCTCTGTATCGGGAGGCCTTAGAGTCTCCGGAACATTGTTCACC

Chromosome

chr5

Cytoband

p15.33

Reference genome

Start

End

1274295/1274180 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-138-5p ; hsa-mir-498 ; hsa-mir-193b-3p ; hsa-mir-335-5p ; hsa-mir-512-5p ; hsa-mir-1207-5p ; hsa-mir-1266-5p ; hsa-mir-1182 ; hsa-mir-181a-5p ; hsa-mir-6776-3p ; hsa-mir-197-3p ; hsa-mir-6740-3p ; hsa-mir-6760-3p ; hsa-mir-532-5p ; hsa-mir-3064-5p ; hsa-mir-422a ; hsa-mir-346 ; hsa-mir-1226-3p ; hsa-mir-1255a ; hsa-mir-1255b-5p ; hsa-mir-143-3p ; hsa-mir-3161 ; hsa-mir-3605-5p ; hsa-mir-3620-3p ; hsa-mir-3682-3p ; hsa-mir-4323 ; hsa-mir-4712-3p ; hsa-mir-4733-3p ; hsa-mir-4758-3p ; hsa-mir-4770 ; hsa-mir-6088 ; hsa-mir-7112-3p

Nearest miRNA

hsa-mir-4635/Upstream/210158; hsa-mir-10397/Downstream/35130;

Nearest TSS

Nearest CpG islands

chr5-CpG: 16/Target, None/Upstream, None/Downstream

Nearest cancer related gene

TERT(OG, No orient, 0)

Upstream sequence

GCACACAGCTCATCATGCCCCCATCACAGCTCATTCCCCCCACTGCCCCCCAGGGCCAACAGTCTGTCCGGTCATGAGCCCAGTGATTGCCCAGGGGAGG

Downstream sequence

CAGGGCCGTGGGCtaaaaccacatcgagtacgattcaaccctgagaaccaacctggaaggcagtaacaggaaggtacatggggcctgcacccttcccaac

Target sequence

CACGACCGCCATCCACAGTCACCACATCAGACCccacgaccgccatccacagtcaccacacatcagaccccacgaccgccatccacagtcaccacacatcagaccccacgaccgccatccacagtcaccacacatcagaccccacgaccgccatccacagtcaccacatcagaccccacgaccgccatccacagtcaccacacatcagaccccacgaccgccatcCACAGTCACCACATCAGACCCCACGACCGC