VISDB Viral Integration Site DataBase

VIS ID

TVIS10020205

Fusion event

HBV-TERT integration

Validated

No

Detection method

VirusScan

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2016

PubMed ID

Virus name

HBV

Reference genome

Start

130

End

1226

Orient

+

Integrated sequence

AGGACTGGGGACCCTGCACCGAACATGGAGAGCACAACATCAGGATTCCTAGGACCCCTGCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCACAGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGAGCACCCACGTGTCCTGGCCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAACTTGTCCTGGCTATCGCTGGATGTGTCTG

Chromosome

chr5

Cytoband

p15.33

Reference genome

Start

End

1273299/1273184 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-138-5p ; hsa-mir-498 ; hsa-mir-193b-3p ; hsa-mir-335-5p ; hsa-mir-512-5p ; hsa-mir-1207-5p ; hsa-mir-1266-5p ; hsa-mir-1182 ; hsa-mir-181a-5p ; hsa-mir-6776-3p ; hsa-mir-197-3p ; hsa-mir-6740-3p ; hsa-mir-6760-3p ; hsa-mir-532-5p ; hsa-mir-3064-5p ; hsa-mir-422a ; hsa-mir-346 ; hsa-mir-1226-3p ; hsa-mir-1255a ; hsa-mir-1255b-5p ; hsa-mir-143-3p ; hsa-mir-3161 ; hsa-mir-3605-5p ; hsa-mir-3620-3p ; hsa-mir-3682-3p ; hsa-mir-4323 ; hsa-mir-4712-3p ; hsa-mir-4733-3p ; hsa-mir-4758-3p ; hsa-mir-4770 ; hsa-mir-6088 ; hsa-mir-7112-3p

Nearest miRNA

hsa-mir-4635/Upstream/209162; hsa-mir-10397/Downstream/36126;

Nearest TSS

Nearest CpG islands

chr5-CpG: 20/Target, None/Upstream, None/Downstream

Nearest cancer related gene

TERT(OG, No orient, 0)

Upstream sequence

TGACTTGATTTTGGCTTTCTTTGGATTTTGGATTAGTAATTGTTAAATTATCCCTTTAAAATGTTTTATTTTTAAATTTCCAGCTTTCTTAATGAATTGG

Downstream sequence

tcaccacacatcagaccccacgaccgccatccacagtcaccacacatcagaccccacgaccgccatccacagtcaccacacatcagaccccacgaccgcc

Target sequence

ACCCACTGCTGGGAGTCCGTGCCCAACCCTGCAGGGCAGTGCCCAGACCTGCTCGATGACGACGGCATCCCTCAGCGGGCTGGTCTCCTGCAGGTGAGCCACGAACTGTCGCATGTACGGCTGGAGGTCTGTCAAGGTAGAGACCTGCCGGCAGAGGAGAGGGCATGAGCCACAAATGTGGCCTGCCCCGGCCAGAGCTGGGCACTTGTTTCTTCCGATCAGGACGTGTGGACCTGCGGCCAAGCCCGATGGCGG