VISDB Viral Integration Site DataBase

VIS ID

TVIS10020232

Fusion event

HBV-PLXNB2 integration

Validated

No

Detection method

VirusScan

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2016

PubMed ID

Virus name

HBV

Reference genome

Start

1176

End

2272

Orient

+

Integrated sequence

CAAGTGTTTGCTGACGCAACCCCCACGGGTTGGGGCTTGGCCATAGGCCATCGGCGCATGCGTGGAACCTTTGTGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCAGCTTGTTTTGCTCGCAGCCGGTCTGGAGCGAAACTTATCGGAACCGACAACTCAGTTGTCCTCTCTCGGAAATACACCTCCTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTCTACGTC

Chromosome

chr22

Cytoband

q13.33

Reference genome

Start

End

50745567/50307138 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-124-3p ; hsa-mir-1-3p ; hsa-mir-615-3p ; hsa-mir-331-3p ; hsa-mir-186-5p ; hsa-mir-222-3p ; hsa-let-7b-5p ; hsa-mir-493-3p

Nearest miRNA

hsa-let-7a-3/Upstream/343151; hsa-mir-12114/Downstream/100304;

Nearest TSS

Nearest CpG islands

chr22-CpG: 94/Target, None/Upstream, None/Downstream

Upstream sequence

AGCTGCCCGGACTTGCCCGTCCTCCTCCTGGGGCCCTCAACCCACGTCCCGGAAGTGGATCCTTCTCCCACGCTGCAGCCTCCCGCTTCGGGTGACTGGA

Downstream sequence

GGACGGCCCCCGGGAGCTCGGGCAAATCCAGGCTCCTGTGCCGCTGAGCCTGGGGCCGGCCCGGAGCGCCCGCACCGCGAGACCATCTCCGCTCGGCGCA

Target sequence

CACGGCTGGATGATCCAAAATAATTCTTTCTTGGCAGGCAGCCGGTGGGGGAGGGGGACTCACATTCCAAACCCTTGTTTTTCTCAGTAACTTCCCTCCTCTACTGGGGCAAGGAACCCCTGGCCAGACCTCAGGCCTCCCAGACCCCCCGGGACAGAGGTGGGCCCCCCATAGGTACCGTGGGAGGACTCAGATGTGCCAGGCCCACCTGCTTGCTTCTCAGTCGGCTCTGGGGATTTCTATGCAACATGCAAA