VISDB Viral Integration Site DataBase

VIS ID

TVIS10020248

Fusion event

HBV-UBE2L3 integration

Validated

No

Detection method

VirusScan

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2016

PubMed ID

Virus name

HBV

Reference genome

Start

808

End

1904

Orient

+

Integrated sequence

TTCTTTTGTCTTTGGGTATACATTTGAACCCTAATAAAACCAAACGTTGGGGCTACTCCCTTAACTTCATGGGATATGTAATTGGAAGTTGGGGTACTTTACCGCAGGAACATATTGTACAAAAACTCAAGCAATGTTTTCGAAAATTGCCTGTAAATAGACCTATTGATTGGAAAGTATGTCAAAGAATTGTGGGTCTTTTGGGCTTTGCTGCCCCTTTTACACAATGTGGCTATCCTGCCTTGATGCCTTTAT

Chromosome

chr22

Cytoband

q11.21

Reference genome

Start

End

21914335/21560046 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-122-5p ; hsa-mir-423-5p ; hsa-mir-93-5p ; hsa-mir-125a-5p

Nearest miRNA

hsa-mir-1286/Upstream/524726; hsa-let-7a-3/Downstream/92935;

Nearest TSS

Nearest CpG islands

None/Target, chr22-CpG: 279/Upstream/7850, chr22-CpG: 72/Downstream/7601

Upstream sequence

AAGAAGACAGAGGCAGACAGGCCAGATGTGGCTGCTGTCCTTAGGGAATTGACAGTCCATGATCTATGAGAATGAGCTGCAGACTGGGAGGCAGGTGTCC

Downstream sequence

TGGTGGCCCTGGCCCAGCTCCCCAGCTCATGTGCCTCTGCAGCGAGTGGTCAGCCCCTTCCCATCTGCACTTTACAAGCCTCATCGCTGAATCCTCCCCA

Target sequence

CAGCATGGGCTCACCAAGCTCCTACCCTCTCCCGGTCCAGCTTTCTCACCTATGAAATAAAAGTGAAgctggacatggtggcccacgcctctaatctcagcagtttgggaggccaaggtgggtggatcacttgagatcaggagattgagaccagcctggctaacatggtgaaaccccatctctactaaaaaacacaaaaattagccggacgtggtggcaggtgcctgtaatcccagctactcgggaggctgaggc