Basic Information
VIS ID
TVIS10020254
Fusion event
HBV-chr12 integration
Validated
No
Detection method
VirusScan
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2016
PubMed ID
27339696
Virus Sequence
Virus name
HBV
Reference genome
NC_003977.1
Start
1106
End
2202
Orient
+
Integrated sequence
TTACAAGGCCTTTCTGTGTAAACAATATCTAAACCTTTACCCCGTTGCCCGGCAACGGTCAGGTCTCTGCCAAGTGTTTGCTGACGCAACCCCCACGGGTTGGGGCTTGGCCATAGGCCATCGGCGCATGCGTGGAACCTTTGTGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCAGCTTGTTTTGCTCGCAGCCGGTCTGGAGCGAAACTTATCGGAACCGACAACTCAGTTGTCCTCTCTCGGAAATA
Host Sequence
Chromosome
chr12
Cytoband
q24.21
Reference genome
GRCh37/hg19
Start
115630961/115193156 (Hg38)
End
115632009/115194204 (Hg38)
Orient
+
Fragile sites / regions
FRA12E ; FRA12C
Nearest miRNA
hsa-let-7i/Upstream/1901548; hsa-mir-1178/Downstream/954356;
Nearest TSS
ENST00000382841/Upstream/115831; ENST00000546696/Downstream/68966;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/456139, chr12-CpG: 44/Downstream/257588
Upstream sequence
GTTGTAAACAAAAACGTACCACGAGAAGTTTTAAAATGAAAAATTATGTTTTAATGGCCAGATTCAtctttggattgcctgcgtcagaatcaagtgggtg
Downstream sequence
AATCCTCTATATGTATATATGTATGTATTTTTTCTCCATACAGTGAGCGCATATATCTGCAATTATGAATCTTGCCTGTTTTACTAAATATCTTGAAAAG
Target sequence
ggagtttgtagtctaatgggaaagacGTAAATTACAACCTTTTCAATTATGTAATTAGGTTTTGGACAAGTGCATTTGAGGAAGTCATCTTAGGTTGGCATGAAGTATAAATACTTagaggtgatattcaagatagttaacaatcagaacagtctacctaccaacaattaggactgatgtggggcttaaacaaTTTACACACTGGTTGAAGGTGAGCTCCTTTTGGGTGGGACCAGGCAGGAGAGGATGGTGATG
Reference
Cao, S., et al.Divergent viral presentation among human tumors and adjacent normal tissues. Sci Rep,2016, 6: 28294.
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