VISDB Viral Integration Site DataBase

VIS ID

TVIS10020259

Fusion event

HBV-PROSER3 integration

Validated

No

Detection method

VirusScan

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2016

PubMed ID

Virus name

HBV

Reference genome

Start

1

End

1051

Orient

-

Integrated sequence

TCCACAACATTCCACCAAGCTCTGCTAGATCCCAGAGTGAGGGGCCTATATTTTCCTGCTGGTGGCTCCAGTTCCGGAACAGTAAACCCTGTTCCGACTACTGCCTCACCCATATCGTCAATCTTCTCGAGGACTGGGGACCCTGCACCGAACATGGAGAGCACAACATCAGGATTCCTAGGACCCCTGCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCACAGAGTCTAGACTCG

Chromosome

chr19

Cytoband

q13.12

Reference genome

Start

End

36256240/35765339 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-331-3p ; hsa-mir-196a-5p ; hsa-mir-1202 ; hsa-mir-128-3p ; hsa-mir-185-3p ; hsa-mir-216a-3p ; hsa-mir-221-5p ; hsa-mir-3150a-5p ; hsa-mir-3150b-5p ; hsa-mir-3613-3p ; hsa-mir-3614-3p ; hsa-mir-3681-3p ; hsa-mir-3972 ; hsa-mir-4258 ; hsa-mir-4283 ; hsa-mir-4297 ; hsa-mir-4438 ; hsa-mir-4489 ; hsa-mir-4684-5p ; hsa-mir-4707-3p ; hsa-mir-4731-5p ; hsa-mir-4755-3p ; hsa-mir-4793-5p ; hsa-mir-4794 ; hsa-mir-5006-5p ; hsa-mir-5095 ; hsa-mir-548c-3p ; hsa-mir-548v ; hsa-mir-5581-5p ; hsa-mir-6502-3p ; hsa-mir-664a-5p ; hsa-mir-6789-3p ; hsa-mir-7151-3p ; hsa-mir-8073

Nearest miRNA

hsa-mir-10395/Upstream/418662; hsa-let-7e/Downstream/3644284;

Nearest TSS

Nearest CpG islands

None/Target, chr19-CpG: 112/Upstream/5883, chr19-CpG: 58/Downstream/9993

Upstream sequence

GAATATCCGGCAGTTTATTATGCCTGTGGTGAGTGCCCGCTCCTCCCGTGTCATCAAGACACCCCGGCGATTTATGGATGAAGACCCCCCCAAACCCCCA

Downstream sequence

attgcctgagctcaggagtttgagaccagcctggccaatgtggcgaaacccggtatctactaaaaatacaaaaattagccacgcgtggtacataatggtg

Target sequence

tagaatgctctgatgaagcagctctgATCTGGGAGGTGGGATCCATCCTCCTCCAACCATGATTTGTCCATGAAAGGTGCTAATCCAccgggcgcggtggctcacgcctgtaatcccagcactttaggagactgaggtgggcggatcacctgaggtcgcgagtttgagaccagcctgaccaacatggagaagccctgtctctactaaaaatacaaaattagccgagcgtggtggcgcatgcctgtaatcccaggt