VISDB Viral Integration Site DataBase

VIS ID

TVIS10020276

Fusion event

HBV-PSMB7 integration

Validated

No

Detection method

VirusScan

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2016

PubMed ID

Virus name

HBV

Reference genome

Start

1199

End

2295

Orient

+

Integrated sequence

CACGGGTTGGGGCTTGGCCATAGGCCATCGGCGCATGCGTGGAACCTTTGTGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCAGCTTGTTTTGCTCGCAGCCGGTCTGGAGCGAAACTTATCGGAACCGACAACTCAGTTGTCCTCTCTCGGAAATACACCTCCTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTCTACGTCCCGTCGGCGCTGAATCCCGCGGA

Chromosome

chr9

Cytoband

q33.3

Reference genome

Start

End

127171427/124409148 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-26b-5p ; hsa-mir-615-3p ; hsa-mir-18a-3p ; hsa-mir-3180-5p ; hsa-mir-525-5p ; hsa-mir-520a-5p ; hsa-mir-3194-5p

Nearest miRNA

hsa-let-7a-1/Upstream/922478; hsa-mir-12126/Downstream/283294;

Nearest TSS

Nearest CpG islands

None/Target, chr9-CpG: 64/Upstream/149638, chr9-CpG: 32/Downstream/5939

Upstream sequence

ctAATTCTCGTTTTTAATCATAGTCCTTGATTAATAGTCCTTAACGATATATCCTGGAATCTAATTTTTTGTTCATTATATATTTTGAAAATATTTCTTC

Downstream sequence

ACATGTACTAGCAATATAAAAGGAAGAGAGGAAGGGAAGAACTTAAGagacagaagactggaataacatacaccaaaccaagagtgatgctccctgaatg

Target sequence

tcaagtcatccaccatgcactgcctttaagtgagccatgatcatgccactgcactccagcctgggcaacagaaagagaccctatctaaactaaaataaaaTTTAACAACCATGCTGCATTTtctcctgcgctactgacggtagtacaacgtttgtcaagggagagctttgacaacatctttcaaaatgttaaatgtgcaaaactaaataaatgtgcatttattctagaatacaggctaaggaattaaatcacatg