VISDB Viral Integration Site DataBase

VIS ID

TVIS10020278

Fusion event

HBV-ASTN2 integration

Validated

No

Detection method

VirusScan

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2016

PubMed ID

Virus name

HBV

Reference genome

Start

1199

End

2295

Orient

+

Integrated sequence

CACGGGTTGGGGCTTGGCCATAGGCCATCGGCGCATGCGTGGAACCTTTGTGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCAGCTTGTTTTGCTCGCAGCCGGTCTGGAGCGAAACTTATCGGAACCGACAACTCAGTTGTCCTCTCTCGGAAATACACCTCCTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTCTACGTCCCGTCGGCGCTGAATCCCGCGGA

Chromosome

chr9

Cytoband

q33.1

Reference genome

Start

End

119869835/117107556 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

FRA9E ; FRA9B

Target gene

miRNAs that regulate target gene

hsa-mir-26b-5p ; hsa-mir-526b-5p ; hsa-mir-1253 ; hsa-mir-591 ; hsa-mir-6761-5p ; hsa-mir-5571-5p ; hsa-mir-6880-5p ; hsa-mir-8085 ; hsa-mir-6746-5p ; hsa-mir-6731-5p ; hsa-mir-6797-5p ; hsa-mir-1249-5p ; hsa-mir-765 ; hsa-mir-6077 ; hsa-mir-766-5p ; hsa-mir-6133 ; hsa-mir-6130 ; hsa-mir-6129 ; hsa-mir-6127 ; hsa-mir-4510 ; hsa-mir-6760-5p ; hsa-mir-4419a ; hsa-mir-4779 ; hsa-mir-6891-5p ; hsa-mir-3173-3p ; hsa-mir-5703 ; hsa-mir-4516 ; hsa-mir-4434 ; hsa-mir-4784 ; hsa-mir-3150b-3p ; hsa-mir-6770-5p ; hsa-mir-124-5p ; hsa-mir-6867-5p ; hsa-mir-5195-5p ; hsa-mir-8485 ; hsa-mir-5010-3p ; hsa-mir-2113 ; hsa-mir-6738-3p ; hsa-mir-544a ; hsa-mir-6071 ; hsa-mir-6828-3p ; hsa-mir-3152-3p ; hsa-mir-1251-3p

Nearest miRNA

hsa-let-7a-1/Upstream/2896979; hsa-mir-12126/Downstream/3137423;

Nearest TSS

Nearest CpG islands

None/Target, chr9-CpG: 64/Upstream/419020, chr9-CpG: 163/Downstream/305419

Upstream sequence

ccttgcacaggtccctggggccccgggccaaacgggtcgtcccctgatccctctcctggccccTGGCTCCCCTCCAGCCCCGGGACCTTGCGGGGCCCTC

Downstream sequence

AATAGttcaattttctcacattctttttgcgttttgatgtccagaattgggcatgctaattcaggtgtgatctgacccgcatagagcaataatggactac

Target sequence

ATTTTTATTAATTCCTTCAGCCATTCCTTATATGtttaaaaattataatttttgaattataaaGTCAGTACATATTTATTGTAGAAATGTTTTCAAAAATAAGAAAGGCACAAAGAAGAAAATAATAATCAAGTCAAATTTTATTACTCCCAACTGACTTCTCTTACTTTGAGATTTTAACAGTGCATTTATATGCATACGTTTTTACAACTAGGTTTCATTGTCTTGTTACTTGAGCATATCCTGTGAATTTTG