VISDB Viral Integration Site DataBase

VIS ID

TVIS10020287

Fusion event

HBV-TLE4 integration

Validated

No

Detection method

VirusScan

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2016

PubMed ID

Virus name

HBV

Reference genome

Start

1199

End

2295

Orient

+

Integrated sequence

CACGGGTTGGGGCTTGGCCATAGGCCATCGGCGCATGCGTGGAACCTTTGTGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCAGCTTGTTTTGCTCGCAGCCGGTCTGGAGCGAAACTTATCGGAACCGACAACTCAGTTGTCCTCTCTCGGAAATACACCTCCTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTCTACGTCCCGTCGGCGCTGAATCCCGCGGA

Chromosome

chr9

Cytoband

q21.31

Reference genome

Start

End

82327665/79712750 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-155-5p ; hsa-mir-548b-3p ; hsa-mir-335-5p ; hsa-mir-186-5p ; hsa-mir-103a-3p ; hsa-mir-26b-5p ; hsa-mir-16-5p ; hsa-let-7d-5p ; hsa-mir-193b-3p ; hsa-mir-221-3p ; hsa-mir-195-5p ; hsa-mir-15a-5p ; hsa-mir-15b-5p

Nearest miRNA

hsa-mir-101-2/Upstream/8901618; hsa-let-7a-1/Downstream/4256998;

Nearest TSS

Nearest CpG islands

None/Target, chr9-CpG: 64/Upstream/138057, chr9-CpG: 255/Downstream/1974474

Upstream sequence

cttgccgagggtcgaagctcaggtccttgcacaggtccctggggccccgggccaaacgggtcgtcccctgatccctctcctggccccTGGCTCCCCTCCA

Downstream sequence

TTTCAACATAAGCCAAAAATGGCCCTTCTCCTTCACCTGCTACTCAAATGAGACTTCTATGGCTAGTGTATAACTATTTGATTAACATCACGGTACTAAT

Target sequence

TGACTCAGATGGTGCTTCTGAGTCTTGGGCTGACTTCCCTTCATCAGTTTTAACTTTCGATGTTATAAAATGTTTAAATGTTTAAGATCCTTTAGGGTGGGTTAATGGATTGGAGGATTGTTGAGAATTTTTGTTTATGAGAGTGACAGAGTCACATCTACTGCAGTTGGCAAATGACACTTTACCAGGAAAATGACACTACTAaaaagcatgtggtgcagtcaacagagtatggttttgggagtgtgacagatc