VISDB Viral Integration Site DataBase

VIS ID

TVIS10020290

Fusion event

HBV-EML6 integration

Validated

No

Detection method

VirusScan

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2016

PubMed ID

Virus name

HBV

Reference genome

Start

1322

End

2418

Orient

+

Integrated sequence

TATCGGAACCGACAACTCAGTTGTCCTCTCTCGGAAATACACCTCCTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTCTACGTCCCGTCGGCGCTGAATCCCGCGGACGACCCGTCTCGGGGCCGTTTGGGCCTCTACCGTCCCCTTCTTCATCTGCCGTTCCGGCCGACCACGGGGCGCACCTCTCTTTACGCGGTCTCCCCGTCTGTGCCTTCTCATCTGCCGGACCG

Chromosome

chr2

Cytoband

p16.1

Reference genome

Start

End

55011062/54783925 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

FRA2S ; FRA2D ; FRA2H

Target gene

miRNAs that regulate target gene

hsa-mir-302c-5p ; hsa-mir-215-5p ; hsa-mir-3143 ; hsa-mir-192-5p ; hsa-mir-6759-3p ; hsa-mir-302d-5p ; hsa-mir-302b-5p ; hsa-mir-543 ; hsa-mir-5582-3p ; hsa-mir-548f-3p ; hsa-mir-548e-3p ; hsa-mir-548az-3p ; hsa-mir-548ar-3p ; hsa-mir-548a-3p

Nearest miRNA

hsa-mir-1301/Upstream/933672; hsa-mir-10b/Downstream/1199042;

Nearest TSS

Nearest CpG islands

None/Target, chr2-CpG: 135/Upstream/57526, chr2-CpG: 129/Downstream/265494

Upstream sequence

tagtagcagaacataggttagtaggggacaaaaggatatagaactgtcttgtgtgggaatacagacaatggcatataaaagtatcaagctgtactgattg

Downstream sequence

ttcatgttccataatttattgaactgtttcaatttttttttgagataaggtcttgtggtattgcccaggctggagtacagtcgtgatcatagttcatggt

Target sequence

gcgtctcattcgtaaagagaagaaaaggttagcacctaatttagggctgctgggatgattaaataatctgtgtaaagggtttagcttcctgtctaatatatagcaagagcccagtaaatcatagctgtttttattGCTGTCATTGCCCAATTAGCTCTGTCCTTGTGGAATATTCTACGTGGTAGGGAAGTTAATATAGGTATGTATGCGTGCATATATTATAGTCGATCAGTAAATAATAACTAATAAAAGTTA